Effects of surgery on the cancer stem cell niche

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
D P O'LearyH P Redmond

Abstract

Recent identification of a cancer stem cell (CSC) phenotype in solid tumors has greatly enhanced the understanding of the mechanisms responsible for cancer cell metastasis. In keeping with Pagets 'seed and soil' theory, CSCs display dependence upon stromal derived factors found within the niche in which they reside. Inflammatory mediators act as a 'fertilizer' within this niche when interacting with CSCs at the tumor-stromal interface and can potentiate the metastatic ability of CSCs. Interestingly, the same components of the pro-inflammatory milieu experienced by cancer patients perioperatively are known to promote the metastagenic potential of CSCs. On the basis of this observation we discuss how surgery-induced inflammation potentiates colon CSC involvement in the metastatic process. We hypothesize that the high rates of recurrence and metastasis associated with tumor resection are potentiated by the effects of surgery-induced inflammation on CSCs. Finally we discuss potential therapeutic strategies for use in the perioperative window to protect cancer patients from the oncological effects of the pro-inflammatory milieu.

References

Aug 1, 1992·The British Journal of Surgery·R J BaigrieP J Morris
Aug 6, 2000·British Journal of Anaesthesia·J P Desborough
Aug 24, 2001·Journal of Surgical Oncology·S LyassO Jurim
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Oct 16, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masataka IkedaTakashi Satomi
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Dec 10, 2003·The Lancet Oncology·J C CoffeyH P Redmond
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Jan 16, 2007·Cancer Cell·Christopher CalabreseRichard J Gilbertson
Dec 7, 2007·The Journal of Clinical Investigation·Pasquale SansoneMassimiliano Bonafè
Jun 7, 2008·Cellular and Molecular Life Sciences : CMLS·L VerstrepenR Beyaert
Jan 21, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J WindW A Bemelman
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emmanuelle Charafe-JauffretMax S Wicha
Dec 30, 2009·Annals of Surgical Oncology·Peter M NearyHenry P Redmond
Jan 13, 2010·Cell·Mi-Young KimJoan Massagué
Oct 5, 2010·Current Colorectal Cancer Reports·Joshua E Allen, Wafik S El-Deiry
Dec 3, 2010·The Journal of Pathology·Malcolm R AlisonLinda J Nicholson
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hisae IinumaMasaki Mori
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Max S Wicha, Daniel F Hayes
Jun 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Carles Gaston-MassuetJuan Pedro Martinez-Barbera
Jun 22, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bishoy FaltasWafik S El Deiry
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Masahisa JinushiHideaki Tahara
Jul 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco CreaWilliam Farrar
Sep 13, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Marco ErreniPaola Allavena
Nov 30, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yael GoldfarbShamgar Ben-Eliyahu
Dec 14, 2011·The International Journal of Developmental Biology·Marc Mareel, Susana Constantino
Dec 23, 2011·Journal of Gastroenterology and Hepatology·Matthias Ernst, Robert G Ramsay
Jan 13, 2012·Nature Reviews. Cancer·Long V NguyenConnie J Eaves
Jan 24, 2012·Cell·Andrew D RhimBen Z Stanger

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Citations

Feb 15, 2017·Veterinary and Comparative Oncology·M Milovancev, D S Russell
Jul 19, 2018·Current Opinion in Anaesthesiology·Juan P Cata
Sep 5, 2019·Journal of Neuro-oncology·Clémentine FulbertDavid Ratel
Sep 8, 2020·Stem Cell Reviews and Reports·Sau Har LeeThamil Selvee Ramasamy
Jan 15, 2019·Regional Anesthesia and Pain Medicine·Andres MissairOscar De Leon Casasola
Mar 7, 2021·Cells·Michael R ShurinGalina V Shurin
Aug 31, 2021·JAMA Network Open·Christina A FlemingHenry P Redmond

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