PMID: 1191449Aug 1, 1975

Effects of sustained isometric handgrip on praecordial accelerocardiogram in normal subjects and in patients with heart disease

British Heart Journal
L HumeS R Reuben


The effects of isometric exercise on the maximum amplitude of the praecordial accelerocardiogram (as represented by the DE deflection) have been compared in 6 normal subjects (group 1), 12 patients with aortic stenosis (group 2), and 16 patients with myocardial disease (group 3). Whereas the tachycardia and pressor effects of isometric exercise were identical in all three groups, the normal subjects showed a significant decrease in DE during handgrip of 10 +/- 4 per cent (P less than 0.05) as compared with the insignificant increases of 8.5 +/- 6 per cent (P greater than 0.5), and 4 +/- 3.5 per cent (P greater 0.3) observed in the patients in groups 2 and 3. This response in the normal subjects differed significantly from the responses observed in the patients in groups 2 (P less than 0.02) and 3 (P less than 0.01). Of the patients in each of groups 2 and 3, 50 per cent responded abnormally to handgrip in that they showed a significant increase in DE. In the patients with aortic stenosis this subgroup of patients differed from the remainder in that they had a higher resting cardiac index (P less than 0.05). In the patients with myocardial disease this subgroup was characterized by a significantly lower resting left ventricular ...Continue Reading


Apr 1, 1973·The American Journal of Cardiology·H P KrayenbuehlH Mehmel
Jul 1, 1973·British Heart Journal·W GrossmanL Dexter
Jul 1, 1973·European Journal of Clinical Investigation·S R Reuben, W A Littler
Jan 1, 1974·The American Journal of Cardiology·P LudbrookR A O'Rourke
Mar 1, 1972·The American Journal of Cardiology·H P KrayenbuehlI Amende
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