Effects of Switching to Electronic Cigarettes with and without Concurrent Smoking on Exposure to Nicotine, Carbon Monoxide, and Acrolein

Cancer Prevention Research
Hayden McRobbiePeter Hajek

Abstract

Concern has been raised about the presence of toxicants in electronic cigarette (EC) aerosol, particularly carbonyl compounds (e.g., acrolein) that can be produced by heating glycerol and glycols used in e-liquids. We investigated exposure to carbon monoxide (CO), nicotine (by measuring cotinine in urine), and to acrolein (by measuring its primary metabolite, S-(3-hydroxypropyl)mercapturic acid (3-HPMA) in urine) before and after 4 weeks of EC (green smoke, a "cig-a-like" EC, labeled 2.4% nicotine by volume) use, in 40 smokers. Thirty-three participants were using EC at 4 weeks after quitting, 16 (48%) were abstinent (CO-validated) from smoking during the previous week (EC only users), and 17 (52%) were "dual users." A significant reduction in CO was observed in EC-only users [-12 ppm, 95% confidence interval (CI), -16 to -7, 80% decrease) and dual users (-12 ppm, 95%CI, -19 to -6, 52% decrease). Cotinine levels also declined, but to a lesser extent (EC-only users: -184 ng/mg creatinine; 95% CI, -733 to -365, 17% decrease; and dual users: -976 ng/mg creatinine; 95%CI, -1,682 to -270, 44% decrease). Mean 3-HPMA levels had decreased at 4 weeks by 1,280 ng/mg creatinine (95%CI, -1,699 to -861, 79% decrease) in EC-only users and by...Continue Reading

References

Oct 13, 2006·Regulatory Toxicology and Pharmacology : RTP·Gerhard SchererKirsten Riedel
Jan 19, 2008·Molecular Nutrition & Food Research·Jan F Stevens, Claudia S Maier
May 2, 2008·Annals of the New York Academy of Sciences·Yong Seek Park, Naoyuki Taniguchi
Mar 26, 2009·Chemical Research in Toxicology·Steven G CarmellaStephen S Hecht
Aug 9, 2011·Molecular Nutrition & Food Research·Riyi ShiWenjing Sun
Oct 14, 2011·Molecular Nutrition & Food Research·Kiflai Bein, George D Leikauf
Oct 26, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Karl Fagerström
Jul 5, 2012·Annals of the New York Academy of Sciences·Nadia MorettoFabrizio Facchinetti
Jan 30, 2013·International Journal of Environmental Research and Public Health·Pasquale CaponnettoRiccardo Polosa
Mar 8, 2013·Tobacco Control·Maciej Lukasz GoniewiczNeal Benowitz
Apr 12, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Emma BeardRobert West
May 17, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Leon KosmiderMaciej Lukasz Goniewicz
Aug 8, 2014·Journal of the American Heart Association·Natasha DeJarnettAruni Bhatnagar
Aug 15, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Peter HajekHayden McRobbie
Oct 23, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stephen S HechtDorothy K Hatsukami
Oct 30, 2014·International Journal of Environmental Research and Public Health·Kanae BekkiNaoki Kunugita
May 23, 2015·Addiction·Konstantinos E FarsalinosKonstantinos Poulas

❮ Previous
Next ❯

Citations

Feb 3, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Margaret NolanDavid O Warner
Jan 26, 2016·Drug and Alcohol Dependence·Jean-François Etter
May 23, 2015·Addiction·Konstantinos E FarsalinosKonstantinos Poulas
Mar 31, 2016·Lancet·David J NuttDavid Sweanor
Jun 21, 2016·European Journal of Clinical Investigation·Davide CampagnaRiccardo Polosa
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Maciej L GoniewiczNeal L Benowitz
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ellen MeierMatthew J Carpenter
Oct 28, 2016·Regulatory Toxicology and Pharmacology : RTP·Ana S CravoTanvir Walele
Mar 24, 2017·Nature Reviews. Cardiology·Neal L Benowitz, Joseph B Fraiman
Jun 8, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jean-François Etter
Apr 7, 2018·Internal Medicine Journal·Colin P Mendelsohn
Mar 25, 2018·Pharmacotherapy·Andrea S FranksSarah McBane
Oct 31, 2017·Journal of Dual Diagnosis·Gerald W ValentineMehmet Sofuoglu
Sep 14, 2016·The Cochrane Database of Systematic Reviews·Jamie Hartmann-BoycePeter Hajek
Jun 2, 2018·Expert Review of Respiratory Medicine·Alexsandra RatajczakMaciej Goniewicz
Sep 12, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Christine D CzoliDavid Hammond
Nov 23, 2018·The European Respiratory Journal·Robert BalsFrancesco Blasi
Mar 19, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Úrsula MartínezThomas H Brandon
Aug 4, 2019·Expert Review of Respiratory Medicine·Riccardo PolosaMassimo Caruso
May 20, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Suzaynn F SchickAruni Bhatnagar
Dec 13, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dorothy K HatsukamiPeter G Shields
Feb 10, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·B P McDonnellC L Regan
Feb 12, 2020·Critical Reviews in Toxicology·Irene YangJeannie Rodriguez
Jul 29, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·John R HughesNicholas Morley
Dec 15, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Harry Tattan-BirchLion Shahab
May 19, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jennifer L PearsonDavid B Abrams
Jan 15, 2016·The Medical Journal of Australia·Colin P Mendelsohn
Sep 12, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Elaine K RoundEckhardt Schmidt
Oct 27, 2018·Therapeutic Advances in Drug Safety·Ashley SchermanCindy McEvoy
Aug 24, 2018·Environmental Health : a Global Access Science Source·Sipeng ShenDavid C Christiani
Apr 14, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Cheryl OnckenHeather Z Sankey
Dec 6, 2019·Asia-Pacific Journal of Public Health·Coral Gartner, Harmy Mohamed Yusoff

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