PMID: 15244858Jul 13, 2004Paper

Effects of synaptic conductance on the voltage distribution and firing rate of spiking neurons

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Magnus J E Richardson

Abstract

A neuron in an active cortical circuit is subject to a fluctuating synaptic drive mediated by conductance changes. It was recently demonstrated that synaptic conductance effects in vivo significantly alter the integrative properties of neurons. These effects are missed in models that approximate the synaptic drive as a fluctuating current. Here the membrane-potential distribution and firing rate are derived for the integrate-and-fire neuron with delta correlated conductance-based synaptic input using the Fokker-Planck formalism. A number of different input scenarios are examined, including balanced drive and fluctuation changes at constant conductance, the latter of which corresponds to shifts in synchrony in the presynaptic population. This minimal model captures many experimentally observed conductance-related effects such as reduced membrane-potential fluctuations in response to increasing synaptic noise. The solvability of the model allows for a direct comparison with current-based approaches, providing a basis for assessing the validity of existing approximation schemes that have dealt with conductance change. In particular, a commonly used heuristic approach, whereby the passive membrane time constant is replaced by a dri...Continue Reading

References

Mar 7, 1979·Journal of Theoretical Biology·H C Tuckwell
Jan 1, 1987·Biological cybernetics·P Lánský, V Lánská
Feb 21, 1994·Journal of Theoretical Biology·V LánskáC E Smith
Jan 4, 2001·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·P H TiesingaT J Sejnowski
Apr 6, 2001·Physical Review Letters·N BrunelL F Abbott
Aug 20, 2002·Neural Computation·Nicolas Fourcaud, Nicolas Brunel
Aug 27, 2002·Neuron·Frances S ChanceAlex D Reyes
Jan 7, 2003·Physical Review Letters·Rubén MorenoNéstor Parga
Mar 1, 1965·Biophysical Journal·R B STEIN
Oct 28, 2003·Neural Computation·M Rudolph, A Destexhe
Feb 6, 2004·Journal of Neurophysiology·G SilberbergM Tsodyks

❮ Previous
Next ❯

Citations

Apr 15, 2005·Journal of Computational Neuroscience·Magnus J E RichardsonHenry Markram
Nov 27, 2008·Journal of Computational Neuroscience·G ZhengD Martinez
Apr 9, 2009·Journal of Computational Neuroscience·Brian Nils LundstromAdrienne L Fairhall
Oct 22, 2008·Nature Neuroscience·Brian N LundstromAdrienne L Fairhall
Apr 15, 2005·Neural Computation·Magnus J E Richardson, Wulfram Gerstner
Oct 11, 2005·Neural Computation·Xuedong Zhang, Laurel H Carney
Jan 16, 2008·Neural Computation·Brian Nils LundstromAdrienne L Fairhall
Sep 22, 2007·Neural Computation·Eilif MullerKarlheinz Meier
Apr 25, 2009·PLoS Computational Biology·Cheng Ly, Brent Doiron
Dec 29, 2010·PLoS Computational Biology·Tilo SchwalgerBenjamin Lindner
Feb 2, 2011·PLoS Computational Biology·Srdjan Ostojic, Nicolas Brunel
Jan 5, 2012·PLoS Computational Biology·Ashok Litwin-KumarBrent Doiron
Apr 18, 2013·PLoS Computational Biology·Adam Ponzi, Jeffery R Wickens
Aug 11, 2012·Journal of Computational Neuroscience·Chris TrengoveMarkus Diesmann
Mar 1, 2016·Frontiers in Systems Neuroscience·Luca MazzucatoGiancarlo La Camera
Jun 9, 2009·Journal of Physiology, Paris·Martin PospischilAlain Destexhe
Jan 12, 2008·Journal of Neuroscience Methods·Zuzanna PiwkowskaAlain Destexhe
May 6, 2016·Frontiers in Computational Neuroscience·Robert Rosenbaum
Jun 28, 2012·PLoS Computational Biology·Robert RosenbaumBrent Doiron
Mar 31, 2015·PLoS Computational Biology·Maxim VolgushevIan H Stevenson
Nov 9, 2005·Journal of Physiology, Paris·Renaud Jolivet, Wulfram Gerstner
Apr 20, 2017·PLoS Computational Biology·Tilo SchwalgerWulfram Gerstner
May 10, 2006·Journal of Computational Neuroscience·Calin Buia, Paul Tiesinga
Mar 5, 2019·PLoS Computational Biology·Marc de KampsYi Ming Lai
Jun 30, 2006·Journal of Neurophysiology·Giancarlo La CameraStefano Fusi
Oct 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Magnus J E Richardson
Dec 7, 2007·Journal of Neurophysiology·Laurent BadelMagnus J E Richardson
Jun 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Lars Wolff, Benjamin Lindner
Sep 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Laurent BadelMagnus J E Richardson
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Gregor KovacicDavid Cai
Apr 29, 2011·Journal of Neurophysiology·Srdjan Ostojic
Feb 9, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Susanne Ditlevsen, Petr Lansky
Aug 16, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Susanne Ditlevsen, Petr Lansky
Apr 24, 2020·PLoS Computational Biology·Caglar Cakan, Klaus Obermayer
Feb 9, 2017·Biological cybernetics·Hiroaki UmeharaYasushi Naruse
Jul 16, 2017·Physical Review. E·Yi Ming Lai, Marc de Kamps
Nov 6, 2018·Chaos·Giuseppe D'OnofrioPetr Lansky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.