Effects of synbiotics on ileal microbiota

The Indian Journal of Medical Research
Shunichiro KomatsuMasato Nagino

Abstract

Despite advancements in molecular-based methods, the composition of the human ileal microbiota and the effects of synbiotics/probiotics on its microbes remain poorly understood. The aim of this study was to determine the composition of the mucus microbiota in the human ileum and to assess the effects of oral administration of synbiotics on the microbiota. As part of a clinical trial for synbiotics treatment and surgical infection, ileal mucus was sampled when resection of the ileocecal portion was required. The microbiota composition was examined using 16S rRNA-targeted real-time-quantitative polymerase chain reaction. A total of 33 samples from the synbiotics group and 39 from the control group were analyzed. Total numbers of bacteria in the ileum were 108.5 cells/g in the synbiotics group and 108.4 cells/g in the control group, in which obligate anaerobes were dominant over facultative anaerobes. The level of Enterobacteriaceae was significantly lower in the synbiotics group than in the control group. The administered probiotics species Lactobacillus casei strain Shirota and Bifidobacterium breve strain Yakult were detected in 42 and 76 per cent of the synbiotics group, respectively. No significant correlations were observed ...Continue Reading

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Citations

Aug 27, 2019·European Journal of Pharmacology·Rubiya KhursheedKamal Dua
May 25, 2021·Nutrition Reviews·Ifeoma Julieth DikeochaMohammed Abdullah Alshawsh

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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