May 1, 1991

Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs

Peptides
R DoiT Tobe

Abstract

Effects of synthetic human pancreastatin-52 and human pancreastatin-29 on pancreatic secretion and blood flow were examined in rats and dogs. Synthetic human pancreastatin-52 and human pancreastatin-29 were equally potent in suppressing the release of amylase stimulated by cholecystokinin in rats in vivo. However, neither human pancreastatin-52 nor human pancreastatin-29 altered basal and cholecystokinin-stimulated amylase release from isolated dispersed rat pancreatic acini. In studies in dogs, human pancreastatin-29 suppressed releases of amylase and protein stimulated by cholecystokinin, but did not alter pancreatic blood flow. These results suggest that the inhibitory effects of pancreastatin on pancreatic secretion do not involve a direct action on pancreatic acinar cells nor alteration of pancreatic blood flow. Pancreastatin probably is important in regulating exocrine pancreatic secretions as well as endocrine pancreatic secretions.

Mentioned in this Paper

CHGA gene
Cholecystokinin
CCK-33
Pancreatic Secretion Function
Proteins, Recombinant DNA
August Rats
Cholecystokinin Measurement
Regional Blood Flow
Blood Flow
Amylase Measurement

About this Paper

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