PMID: 11914312Mar 27, 2002Paper

Effects of systematic exposure assessment errors in partially ecologic case-control studies

International Journal of Epidemiology
Jonas Björk, U Strömberg

Abstract

In ecologic studies, group-level rather than individual-level exposure data are used. When using group-level exposure data, established by sufficiently large samples of individual exposure assessments, the bias of the effect estimate due to sampling errors or random assessment errors at the individual-level is generally negligible. In contrast, systematic assessment errors may produce more pronounced errors in the group-level exposure measures, leading to bias in ecologic analyses. We focus on effects of systematic exposure assessment errors in partially ecologic case-control studies. Individual-level information on disease status, group membership, and covariates is obtained from registries, whereas the exposure is a group-level measure obtained from an established exposure database. Effects on bias and coverage of 95% CI in various error situations are investigated under the linear risk model, using both simulated and empirical ecologic data on exposures that are binary at the individual level. Our simulations suggest that the bias produced by systematic exposure assessment errors under the linear risk model is generally approximately equal to the ratio of the slope bias and the intercept bias in ordinary linear regression wi...Continue Reading

References

Jun 1, 1979·Journal of Epidemiology and Community Health·V BeralP Fraser
Jan 1, 1992·American Journal of Epidemiology·H BrennerS Greenland
Mar 1, 1989·International Journal of Epidemiology·S Greenland, H Morgenstern
Dec 1, 1994·Occupational and Environmental Medicine·T Sorahan, M S Gilthorpe
Apr 15, 1994·American Journal of Epidemiology·S Greenland, J Robins
Dec 24, 1997·Environmental Health Perspectives·N Künzli, I B Tager
Mar 26, 1998·American Journal of Industrial Medicine·T KauppinenE Pukkala
Feb 4, 1999·Occupational and Environmental Medicine·B G Armstrong
Apr 6, 2000·International Journal of Epidemiology·S Greenland
Feb 24, 2001·Scandinavian Journal of Work, Environment & Health·M AlbinL Hagmar

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Citations

Mar 8, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·S MarchE Swart
Nov 25, 2003·Environmental Health : a Global Access Science Source·Yan CuiRoger Detels
Jul 7, 2007·Environmental Health : a Global Access Science Source·Thomas F Webster
Nov 9, 2007·Environmental Health : a Global Access Science Source·Anna OudinUlf Strömberg
Feb 23, 2010·American Journal of Preventive Medicine·Sharif B MohrFrank C Garland
Mar 27, 2002·International Journal of Epidemiology·Thomas Webster
Jul 3, 2002·Epidemiology·Jonas Björk, Ulf Strömberg
May 19, 2017·Epidemiology·Marc G Weisskopf, Thomas F Webster

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