Effects of systemic antibiotic therapy on bacterial persistence in the respiratory tract of mechanically ventilated patients

Intensive Care Medicine
Stefan VisscherMarc J M Bonten

Abstract

Bacterial respiratory tract colonization predisposes critically ill patients to intensive care unit (ICU)-acquired infections. It is unclear to what extent systemic antibiotics affect colonization persistence. Persistence of respiratory tract colonization, and the effects of systemic antibiotics hereon, were determined in a cohort of ICU patients. Clinical and microbiological data were collected from 715 admitted mechanically ventilated ICU patients with bacterial growth documented in respiratory tract samples. First day of colonization, persistence of colonization and antibiotic effects hereon were analyzed for six groups of pathogens: Pseudomonas aeruginosa, Acinetobacter species, Enterobacteriaceae, Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae. Systemic antibiotics were grouped into 'effective' and 'ineffective' antibiotics, based on in-vitro susceptibility data for the relevant bacteria. The effects of antibiotics were quantified as relative risk (RR) of bacterial persistence in the absence of effective antibiotics. Persistence of colonization differed significantly between pathogens, ranging from 4 days (median) for H. influenzae and Strep. pneumoniae to 8 days for P. aeruginosa. Systemic anti...Continue Reading

References

Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M J BontenC A Gaillard
Mar 1, 1997·Journal of Clinical Microbiology·D C BergmansE E Stobberingh
Apr 1, 1997·The Journal of Antimicrobial Chemotherapy·D C BergmansE E Stobberingh
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·J M SirventA Bonet
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·J L TrouilletC Gibert
Jan 22, 2004·FEMS Microbiology Letters·Iris KerenKim Lewis
Feb 3, 2005·Genetics·Edo KussellStanislas Leibler
Jan 17, 2007·Current Opinion in Pediatrics·Thomas S MurrayBarbara I Kazmierczak
Mar 27, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·K M C VerhammeP Jordens
Jun 19, 2007·Intensive Care Medicine·Carolina A M SchurinkMarc J M Bonten

❮ Previous
Next ❯

Citations

Aug 5, 2009·Intensive Care Medicine·Fabio FerrariUNKNOWN Experimental ICU Study Group
Apr 9, 2008·The Journal of Antimicrobial Chemotherapy·Stefan VisscherMarc J M Bonten
Jun 17, 2015·Intensive Care Medicine·Cédric BretonnièreUNKNOWN Société Française d’Anesthésie et de Réanimation (SFAR)
Feb 1, 2013·Therapeutic Advances in Infectious Disease·João Gonçalves-PereiraPedro Póvoa
Aug 25, 2015·The Cochrane Database of Systematic Reviews·Richard PughGed Dempsey
Jul 1, 2020·Critical Care : the Official Journal of the Critical Care Forum·Hulda R ThorarinsdottirBengt Klarin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Related Papers

Oral Surgery, Oral Medicine, and Oral Pathology
S Cohen, F M Parkins
Oral Surgery, Oral Medicine, and Oral Pathology
L ZACH, G COHEN
Oral Surgery, Oral Medicine, and Oral Pathology
H R Stanley
Oral Surgery, Oral Medicine, and Oral Pathology
H R Stanley
© 2021 Meta ULC. All rights reserved