Effects of systemic estradiol on fear extinction in female rats are dependent on interactions between dose, estrous phase, and endogenous estradiol levels

Hormones and Behavior
Bronwyn M Graham, Elliot Scott

Abstract

Administering estradiol to females during periods of low endogenous estradiol enhances their ability to extinguish fear, the laboratory basis of exposure therapy for anxiety disorders. It has therefore been proposed that estradiol could be a useful adjunct to enhance exposure therapy outcomes. The present study aimed to clarify the boundary conditions under which estradiol could be used for this purpose, by assessing whether the impact of estradiol, administered systemically prior to extinction training, differs depending on dose and estrous phase in adult female rats. Results demonstrated that in rats extinguished during metestrus (naturally low estradiol), a low dose of estradiol reduced freezing during extinction training and augmented extinction recall the following day, whereas a high dose of estradiol had no effect on either extinction training or recall. In rats extinguished during proestrus (naturally high estradiol), a high dose of estradiol impaired extinction recall, whereas a low dose of estradiol had no effect, or impairing effects, on extinction recall in different experiments. A subsequent analysis revealed that estradiol-treated proestrus rats that exhibited impaired extinction recall had significantly higher pr...Continue Reading

Citations

Apr 3, 2020·Stress : the International Journal on the Biology of Stress·Qi SongBenno Roozendaal
Oct 22, 2019·The European Journal of Neuroscience·Harriet L L Day, Carl W Stevenson
Sep 4, 2020·Nature Reviews. Neuroscience·Lisa R TaxierKaryn M Frick
Apr 2, 2019·Frontiers in Neuroscience·Fabíola de Carvalho Chaves de Siqueira MendesMarcia Consentino Kronka Sosthenes
Mar 12, 2020·European Journal of Psychotraumatology·Antonia V SeligowskiTeniel S Ramikie
Sep 13, 2019·Neurobiology of Learning and Memory·Samantha Tang, Bronwyn M Graham
May 16, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bronwyn M Graham, Elliot Scott
Feb 3, 2021·Journal of Cannabis Research·Zackary T MontoyaJeffrey P Smith
Jan 26, 2020·Hormones and Behavior·Samantha Tang, Bronwyn M Graham
Mar 2, 2021·Physiology & Behavior·Milene C CarvalhoThelma A Lovick
Aug 24, 2021·Frontiers in Behavioral Neuroscience·Iryna S Palamarchuk, Tracy Vaillancourt

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