Effects of tachykinins on mucus secretion in human bronchi in vitro.

European Journal of Pharmacology
D F RogersP J Barnes

Abstract

We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.

Citations

May 30, 2008·Pflügers Archiv : European journal of physiology·Juan P IanowskiJohn W Hanrahan
Feb 16, 1993·European Journal of Pharmacology·S Lindberg, J Dolata
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D F Rogers, A Dewar
Jul 1, 1996·The International Journal of Biochemistry & Cell Biology·A M Khawaja, D F Rogers
May 30, 2001·The International Journal of Biochemistry & Cell Biology·S Harrison, P Geppetti
May 22, 2002·Current Opinion in Pharmacology·Duncan F Rogers
Jan 11, 2003·British Journal of Pharmacology·Jonathan E PhillipsMichel R Corboz
Sep 14, 2001·Respirology : Official Journal of the Asian Pacific Society of Respirology·P N ReynoldsM D Holmes
May 22, 2010·Cornea·Hong-Yuan ZhuRoger W Beuerman
Mar 1, 1997·Clinical and Experimental Pharmacology & Physiology·P N ReynoldsR Scicchitano
Feb 1, 1993·Journal of Autonomic Pharmacology·C A MaggiA Giachetti
Jun 1, 1991·British Journal of Pharmacology·S J IrelandM L Stephens-Smith
Jan 1, 1991·Annals of the New York Academy of Sciences·P J Barnes
Mar 1, 1995·Thorax·G F JoosR A Pauwels
Jun 19, 2004·International Archives of Allergy and Immunology·Osamu MukaiyamaMakoto Yamashita
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Azzeddine DakhamaErwin W Gelfand
Mar 1, 1991·The American Review of Respiratory Disease·P J Barnes
Sep 1, 1991·The American Review of Respiratory Disease·G BraunsteinN Frossard
Nov 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Feb 26, 1998·American Journal of Respiratory Cell and Molecular Biology·G W HoyleM Friedman
Sep 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M I LethemC W Davis
Nov 1, 1990·Peptides·G A OlsonA J Kastin
Jul 15, 1994·European Journal of Pharmacology·P J CabotM T Smith
Jul 5, 2005·Expert Opinion on Investigational Drugs·P GeppettiC Bertrand
Jun 16, 2001·Chest·H A Werner
Feb 15, 2005·Pulmonary Pharmacology & Therapeutics·Naoto WatanabeJohn V Priestley
Sep 15, 2004·European Journal of Pharmacology·Osamu MukaiyamaMakoto Yamashita
Nov 17, 2004·Regulatory Peptides·Jochen SpringerAxel Fischer
Jun 1, 1992·Pulmonary Pharmacology·J D Lundgren, J N Baraniuk
Jul 1, 1991·Neuropeptides·N Frossard, J Barnes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.