Effects of target concentration infusion of propofol and tracheal intubation on QTc interval

Anaesthesia
D H KimJ S Lee

Abstract

This study was designed to evaluate the effect of target controlled infusion of propofol on QTc interval and tracheal intubation. Twenty-five unpremedicated, ASA class I or II patients were selected and target concentration infusion of propofol at 5 microg x ml(-1) was used throughout the study. The QTc interval was measured before anaesthetic induction (baseline, T1), 10 min after propofol infusion (T2), immediately after tracheal intubation (T3), and 1 min after tracheal intubation (T4). The QTc interval increased significantly at 10 min after the propofol infusion started compared to baseline (p = 0.003). After tracheal intubation, the QTc interval was further increased when compared to that at T2 (p < 0.0001). The increased QTc interval was within normal limit and no patient had an arrhythmia. In conclusion, although statistically significant, the increase in QTc interval was too small to be clinically significant during propofol infusion. However, the combination of propofol and tracheal intubation must be used carefully in patients with prolonged QTc interval.

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Citations

Dec 18, 2012·Journal of Clinical Monitoring and Computing·Makito OjiKoji Sumikawa
Aug 8, 2009·Critical Care Medicine·Vivek N IyerAlejandro A Rabinstein
Feb 5, 2011·Pediatric Emergency Care·Christine E MikesellBonnie R Rachman
Oct 23, 2010·International Heart Journal·Tadanobu IrieMasahiko Kurabayashi
Dec 7, 2013·British Journal of Anaesthesia·C StaikouE Stavroulakis
Jul 7, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Lukasz J KrzychAndrzej Bochenek
Oct 15, 2009·Anaesthesia·J R Sneyd
Oct 30, 2016·European Journal of Pharmacology·Sheng-Na HanLi-Rong Zhang
Jun 15, 2016·Therapeutic Advances in Drug Safety·Michael J ScaleseToni L Ripley
Sep 1, 2015·Journal of Dental Anesthesia and Pain Medicine·Kyung Jin KimTeo Jeon Shin
Jan 27, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Naoko NiimiKatherine Zaleski

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