PMID: 7541615Jul 1, 1995Paper

Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia

Anesthesiology
F IchinoseW M Zapol

Abstract

Considerable evidence suggests that nitric oxide plays a role in synaptic transmission in the central and peripheral nervous system. Nonselective inhibition of nitric oxide synthase by nitroG-L-arginine methylester (L-NAME) reduces the minimum alveolar concentration of halothane anesthesia. The effects of selective neuronal nitric oxide synthase inhibition on the anesthetic requirements in mice congenitally deficient in neuronal nitric oxide synthase (knockout mice) were examined. Isoflurane minimum alveolar concentration and righting reflex ED50 (RRED50) were determined in knockout and wild-type mice. Subsequently, the effects of intraperitoneal L-NAME on minimum alveolar concentration and RRED50 of knockout and wild-type mice were examined. In a separate experiment, the effects of week-long administration of L-NAME were examined in wild-type mice. Isoflurane minimum alveolar concentration and RRED50 were measured on the 8th day and were repeated after an acute intraperitoneal dose of L-NAME. Targeted disruption of the neuronal nitric oxide synthase gene did not modify isoflurane minimum alveolar concentration and RRED50 of knockout mice. Acute intraperitoneal L-NAME decreased the minimum alveolar concentration and RRED50 of w...Continue Reading

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Citations

Jan 16, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I MiyawakiK Mori
May 21, 1998·Brain Research·D MotzkoH Flohr
Feb 28, 2004·Journal of Pharmacological and Toxicological Methods·Erin L Heinzen, Gary M Pollack
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Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano
Dec 13, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus Sjöblom, Olof Nylander
May 13, 1999·Critical Care Medicine·G Santis, T W Evans
Mar 26, 2003·European Journal of Anaesthesiology·T P WeberM Booke
Mar 26, 2003·European Journal of Anaesthesiology·M SchywalskyH Schwilden
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Mar 26, 2003·European Journal of Anaesthesiology·P BozkurtM Hacibekiroğlu

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