PMID: 11324559Apr 28, 2001Paper

Effects of taurine enhancement of synthesis of TxA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia

Sheng li xue bao : [Acta physiologica Sinica]
D H Hu

Abstract

The results of the present study demonstrated that the concentrations of thromboxane B2 (TxB2a) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and their ratio were significantly increased in the medium of intra-pulmonary arteriolar smooth muscle cells (PASMCs) under acute hypoxia. Under either normoxia or hypoxia the concentration of TxB2 was significantly decreased with addition of taurine, while that of 6-keto-PGF1 alpha was significantly increased. With the addition of indomethacin, however, under similar conditions, the concentrations of both TxB2 and 6-keto-PGF1 alpha were decreased. Furthermore, the effect of indomethacin on TxA2 and 6-keto-PGF1 alpha concentrations could be reversed by taurine.

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