Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer.

Contemporary Clinical Trials Communications
Patricia G WolfLisa Tussing-Humphreys

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer and second leading cause of cancer death in the United States. Recent evidence has linked a high fat and animal protein diet and microbial metabolism of host bile acids as environmental risk factors for CRC development. We hypothesize that the primary bile salt taurocholic acid (TCA) is a key, diet-controlled metabolite whose use by bacteria yields a carcinogen and tumor-promoter, respectively. The work is motivated by our published data indicating hydrogen sulfide (H2S) and secondary bile acid production by colonic bacteria, serve as environmental insults contributing to CRC risk. The central aim of this study is to test whether a diet high in animal protein and saturated fat increases abundance of bacteria that generate H2S and pro-inflammatory secondary bile acids in African Americans (AAs) at high risk for CRC. Our prospective, randomized, crossover feeding trial will examine two microbial mechanisms by which an animal-based diet may support the growth of TCA metabolizing bacteria. Each subject will receive two diets in a crossover design- an animal-based diet, rich in taurine and saturated fat, and a plant-based diet, low in taurine and saturated fat. A mediation...Continue Reading

Citations

Oct 19, 2020·Seminars in Cancer Biology·Soeren Ocvirk, Stephen J D O'Keefe

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Methods Mentioned

BETA
biopsies
chips
X-ray
biopsy
PCR
light microscopy

Clinical Trials Mentioned

NCT03550885

Software Mentioned

Nutrition Data Systems for Research ( NDSR )
NDSR
FreezerWorks
Research Electronic Data Capture ( REDCap )

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