Effects of TCDD on vitamin A status and liver microsomal enzyme activities in a TCDD-susceptible and a TCDD-resistant rat strain

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
R PohjanvirtaJ Tuomisto

Abstract

To investigate the relationship between vitamin A status and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) lethality, the influence of TCDD on tissue and serum vitamin A levels was determined in the most TCDD-susceptible (Long-Evans) and the most TCDD-resistant (Han/Wistar) rat strains. The TCDD LD50 values of these two strains differ by a factor of more than 300. Groups of three rats per strain were used in a dose-response study (given single ip doses of 0, 4, 40, 400, 800 or 1600 micrograms TCDD/kg body weight and killed on day 11) and in a time-course experiment (given single ip doses of 0, 4 and, in the case of Han/Wistar rats only, 1600 micrograms TCDD/kg body weight, and killed on days 4, 11, 23, 50 and 76). The strains showed similar response over the 76-day study with respect to vitamin A levels in the liver, kidneys, testicles and serum after exposure to a sublethal dose of TCDD (4 micrograms/kg body weight). In contrast, TCDD doses lethal to the Long-Evans strain only (40-1600 micrograms/kg, day 11) markedly increased kidney and serum vitamin A levels in Han/Wistar rats, while they were practically without effect in Long-Evans rats. Hepatic cytochrome P-450 concentration, and the activities of 7-ethoxyresorufin O-deethyl...Continue Reading

References

Feb 1, 1987·Pharmacology & Toxicology·R PohjanvirtaK Rozman
Sep 1, 1973·Environmental Health Perspectives·B N GuptaB C Bullock
Jan 1, 1982·Journal of Nutritional Science and Vitaminology·A Morita, K Nakano

❮ Previous
Next ❯

Citations

Oct 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Pohjanvirta, J Tuomisto
Nov 1, 1992·General Pharmacology·P JosephM K Krishnakumari
Feb 15, 1994·Toxicology Letters·R PohjanvirtaJ Tuomisto
Dec 7, 1995·European Journal of Pharmacology·R PohjanvirtaJ Tuomisto
Jun 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·N FletcherH Håkansson
May 1, 1990·Pharmacology & Toxicology·R PohjanvirtaJ Tuomisto
Nov 1, 1990·Pharmacology & Toxicology·R PohjanvirtaJ Tuomisto
Sep 16, 2006·Molecular Nutrition & Food Research·Stefanie Knerr, Dieter Schrenk
Jun 20, 2002·Critical Reviews in Toxicology·Charlotte B Nilsson, Helen Håkansson
Jan 1, 1995·Aesthetic Plastic Surgery·B Guyuron, C Vaughan
Apr 29, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nick FletcherHelen Håkansson
Nov 20, 2018·EFSA Journal·UNKNOWN EFSA Panel on Contaminants in the Food Chain (CONTAM)Laurentius Ron Hoogenboom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.