Effects of tectal grafts on sound localization deficits induced by inferior colliculus lesions in hooded rats

Experimental Neurology
M C Zrull, J R Coleman

Abstract

The goals of this research were to examine the role of the inferior colliculus (IC) in mediating sound localization behavior and the ability of tectal grafts to restore function after IC ablation in the Long-Evans rat. Previous work has suggested that the IC is a major center for processing of information used in localizing sound sources in space. Adult rats were trained on a lick suppression paradigm to discriminate the location of the second pulse in a noise burst pair presented in the horizontal interaural plane. Following baseline testing, rats received bilateral IC lesions, bilateral lesions followed in 1 week by bilateral tectal grafts, or were sham operated. Sound localization ability was then tested 15 to 30 days and 40 to 50 days following surgical procedures. Performance across experimental groups was statistically the same during baseline testing. During the first operative test period lesion-only and grafted animals showed deficits in sound localization ability relative to controls. By the second postoperative test period control and grafted animals did not differ statistically in sound localization ability and performance of both groups was superior to that of lesion-only animals. Histology revealed a similar exten...Continue Reading

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Citations

Jan 8, 2004·Journal of Cognitive Neuroscience·Jennifer M GrohAbigail M Underhill
Mar 8, 2011·BMC Neuroscience·Byoung-Kyong MinSeung-Schik Yoo
Dec 3, 1999·Audiology : Official Organ of the International Society of Audiology·A Polyakov, H Pratt
Jul 6, 2000·Experimental Neurology·J R ColemanK C Ross
Jun 25, 1999·Acta Oto-laryngologica·M C Zrull, J R Coleman

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