Effects of tegaserod and erythromycin in upper gut dysmotility: a comparative study.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Issam NasrRobert Summers

Abstract

Tegaserod may enhance upper gut transit, but, its prokinetic effects on antral/small bowel motility and how this compares with erythromycin is unknown. We prospectively assessed and compared the effects of tegaserod and erythromycin on upper gut motility. In an open label, non-crossover study, 22 patients (M/F=4/18; mean age=37 years) with symptoms of upper gut dysmotility underwent 24-hour ambulatory antroduodenojejunal manometry with a six-sensor solid state probe. The effects of 12 mg oral tegaserod were compared with 125 mg intravenous erythromycin by quantifying pressure wave activity and assessing motor patterns. Motor activity increased (p<0.05) in antrum, duodenum and jejunum with both drugs when compared to baseline period. The motor response with tegaserod was higher (p<0.05) in jejunum and occurred during the second or third hours, whereas with erythromycin, it was higher (p<0.05) in antrum and occurred within 30 minutes. After tegaserod, a 'fed-response' like pattern was seen whereas after erythromycin, large amplitude (>100 mmHg) antral contractions at 3 cycles per minute were seen. Following tegaserod and erythromycin, phase III MMCs occurred in 12 (55%) and 8 (36%) patients respectively (p>0.05). Both drugs incre...Continue Reading

References

May 1, 1975·Journal of Clinical Pharmacology·M S Chow, R A Ronfeld
Apr 12, 1990·The New England Journal of Medicine·J JanssensR Bouillon
Dec 1, 1969·The American Journal of Physiology·J H Szurszewski
Oct 29, 2000·The American Journal of Gastroenterology·E S BonapaceH P Parkman
Nov 7, 2001·Current Gastroenterology Reports·J TackB DeMarchi
Feb 20, 2003·The American Journal of Gastroenterology·Kalyani MagantiMichael P Jones
Dec 1, 1957·The American Journal of Medicine·T R HENDRIXF J INGELFINGER
Nov 18, 2003·Alimentary Pharmacology & Therapeutics·J TackG Vandeplassche
Mar 17, 2004·Alimentary Pharmacology & Therapeutics·H B El-Serag, N J Talley
Aug 25, 2004·Best Practice & Research. Clinical Gastroenterology·Kwang-Jae LeeJan Tack
Jan 26, 2005·The American Journal of Gastroenterology·Michael A KammBrigitte Nault
Mar 31, 2005·Journal of Clinical Gastroenterology·Michael D Gershon
Sep 28, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J J Galligan, S Vanner
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L DegenC Beglinger
Oct 7, 2006·Current Opinion in Gastroenterology·M D Gershon
May 1, 2007·European Journal of Clinical Pharmacology·Juan ZengGuo-Ping Lv

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Citations

Nov 26, 2009·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rita Brun, Braden Kuo
Jan 19, 2016·Current Gastroenterology Reports·Ali RezaieSatish S Rao

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