Effects of telmisartan on TNFα induced PPARγ phosphorylation and insulin resistance in adipocytes

Biochemical and Biophysical Research Communications
Tao FangGuangwei Li

Abstract

Telmisartan is an angiotensin II receptor blocker (ARB) and a partial agonist of peroxisome proliferator activated receptor γ (PPARγ). It has been shown to significantly enhance insulin sensitivity in clinical studies and in vitro experiments. However, the effect of telmisartan on PPARγ in adipocytes remains unknown. 3T3-L1 adipocytes were incubated with tumor necrosis factor α (TNFα) to simulate growth under an inflammatory condition. On this basis, adipocytes were treated with telmisartan at different concentrations for 1 h. Then, the phosphorylation level of PPARγ, glucose uptake, mRNA levels of PPARγ downstream genes and adiponectin secretion of adipocytes were analyzed. Telmisartan reduced the phosphorylation level of PPARγ, altered mRNA expressions of adiponectin, adipsin, leptin, FABP4, GLUT4 and CAP, and promoted the secretion of adiponectin. Furthermore, telmisartan treatment restored the decrease of cellular glucose uptake due to TNFα stimulation. Telmisartan regulated PPARγ phosphorylation and its downstream gene expressions, promoted glucose uptake and acted as an overall insulin sensitizing agent in adipocytes. The specific phosphorylation site of PPARγ affected by telmisartan, the mechanism of telmisartan in regul...Continue Reading

Citations

Jul 23, 2020·PPAR Research·Åsmund Kaupang, Trond Vidar Hansen
Aug 16, 2019·Bioscience Reports·Jia LiuJiyan Leng
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Muluken Altaye AyzaDerbew Fikadu Berhe
Jan 21, 2021·International Journal of Molecular Sciences·Márcia V de CarvalhoAdriana R Silva
Apr 19, 2021·Current Diabetes Reports·Simona CataldiMarianna Aprile
Oct 26, 2021·Journal of Diabetes Investigation·Hiroki SanoYoshinori Mitamura

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