Effects of telomerase inhibitor on epigenetic chromatin modification enzymes in malignancies

Journal of Cellular Biochemistry
Cigir Biray AvciCumhur Gunduz

Abstract

Telomerase has a critical role in cell proliferation, tumor maintaining, and therapy resistance, which act by modifying many signaling pathways. 2-[(E)-3-Naphtalen-2-yl-but-2-enoylamino]-benzoic acid (BIBR1532) is one of the most studied telomerase inhibitors, and it targets telomerase components TERC and TERT. In this novel study, we aimed to investigate the epigenetic effects of BIBR1532 on both hematologic malignancies and solid tumors. K-562 human chronic myeloid leukemia cell line and U87MG glioblastoma cell line were compared with control groups without BIBR1532 treatment. Cytotoxic effects of BIBR1532 were determined by using WST-1 assay. Apoptotic effects of BIBR1532 were detected by using annexin V method. To assess expression changes in the human epigenetic chromatin modification enzyme genes, total RNA was isolated from K-562 and U87MG cells treated with BIBR1532 and untreated control cells. BIBR1532 induced 2.41-fold apoptotic cell death in U87MG cell lines compared with control groups. Apoptosis was slightly induced in K-562 cells with BIBR1532 treatment compared with control cells. We observed that BIBR1532 also regulates similar genes in both cell lines, and it is useful on epigenetic mechanisms. As a result, tel...Continue Reading

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Citations

Jul 31, 2019·Medicinal Research Reviews·Xing ChenXin-Hua Liu
Oct 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanpan GuoMiao Du
Apr 4, 2021·Cancers·Nathalie OlympiosMaxime Fontanilles
Feb 2, 2022·Cell Biochemistry and Function·Ali RafatHojjatollah Nozad Charoudeh

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