Effects of temperature alterations on population and cellular activities in hippocampal slices from mature and immature rabbit

Brain Research
K F Shen, P A Schwartzkroin

Abstract

Effects of temperature on population spike and cellular activities have been assessed in the CA1 region of hippocampal slices from mature and immature rabbit. In field potential recordings, population spike amplitude was maximal at near 30 degrees C for both mature and immature tissue, and fell off as temperature was either raised (to a maximum of 44 degrees C) or lowered (to a minimum of 20 degrees C). With cooling below 30 degrees C, population spikes decreased in amplitude and became broader; stimuli always elicited some response, and changes due to cooling were reversible. With increases in temperature, however, irreversible decrease and/or loss of population spikes occurred when tissue was warmed beyond 43 degrees C. Input-output curves established for mature and immature slices indicated that, at all temperatures, population spike amplitude grew more rapidly with small increases in stimulus intensity in immature slices as compared to mature slices. Intracellular recordings were made from CA1 pyramidal cells in mature and immature hippocampal slices. For both mature and immature tissues, moderate warming (to 40 degrees C) produced membrane hyperpolarizations in many cells, especially in the mature hippocampus. Increasing t...Continue Reading

References

Jun 3, 1977·Brain Research·P A Schwartzkroin
Apr 1, 1972·Acta Physiologica Scandinavica·P AndersenE Pasztor
Mar 29, 1974·Experimental Brain Research·M R KleeD S Faber
Jan 1, 1971·Experimental Brain Research·P AndersenK K Skrede
Jul 1, 1968·The Journal of General Physiology·D O Carpenter, B O Alving
Jan 1, 1983·The Journal of Physiology·S D Head
Dec 1, 1984·Epilepsia·T L BabbP H Crandall
Dec 1, 1984·Journal of Neuroscience Methods·B A MacVicar
Jan 1, 1983·Bioelectromagnetics·D L HjeresenJ Diaz
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum

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Citations

Jun 21, 2001·Annals of Neurology·X F Yang, S M Rothman
Sep 3, 2002·Annals of Neurology·Michelle T LiebregtsL Stan Leung
Dec 1, 1993·Pflügers Archiv : European journal of physiology·W Jarolimek, U Misgeld
Apr 3, 1992·Brain Research·J Berg-Johnsen, I A Langmoen
Jun 20, 2000·Neuroscience·M VolgushevU T Eysel
Aug 10, 2000·Proceedings of the National Academy of Sciences of the United States of America·S GaspariniE Cherubini
Apr 13, 2012·Journal of Neurophysiology·Eran StarkGyörgy Buzsáki
May 24, 2014·Brain Research·Mirja SteinbrennerMartin Holtkamp
Aug 5, 2014·Journal of Thermal Biology·Anatoly A MokrushinSergey E Borovikov
Dec 11, 2007·Canadian Journal of Physiology and Pharmacology·Dragan HrncićOlivera Stanojlović
Feb 8, 2013·Neurochemical Research·Yasser A KhadrawyHaitham S Mohammed
Jan 7, 2016·Annals of Clinical and Translational Neurology·Jerome NiquetClaude G Wasterlain
Jul 23, 2015·Epilepsy & Behavior : E&B·Jerome NiquetClaude G Wasterlain
Jul 4, 2008·Resuscitation·Xiaofeng JiaRomergryko G Geocadin
Apr 27, 2007·Neurobiology of Disease·Peter A AbdelmalikPeter L Carlen
Apr 28, 2009·Journal of Neuroscience Research·Lintao Qu, L Stan Leung
Mar 1, 2015·Pflügers Archiv : European journal of physiology·Tom A CoatesMark D Baker
Jul 18, 2006·Neurobiology of Disease·F C SchmittM Holtkamp
Mar 1, 2012·Brain Research·Alexander B KowskiMartin Holtkamp
Jun 5, 2015·Current Treatment Options in Pediatrics·Robert NewmyerEricka L Fink
Aug 4, 2016·Scientific Reports·Komal KampasiEuisik Yoon
Jul 25, 2007·Progress in Brain Research·John A D'AndreaEleanor R Adair
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K HiramatsuK S Lee
Oct 1, 1996·Anesthesiology·M B MaclverF A Monroe
Mar 30, 2007·Journal of Neurophysiology·Stephen D Glasgow, C Andrew Chapman
Oct 11, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph M SantinLynn K Hartzler
Aug 22, 2002·The International Journal of Neuroscience·Mark M SteckerAlbert T Cheung
Jul 5, 2018·The Journal of General Physiology·Filip TouskaKatharina Zimmermann

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