PMID: 3320012Nov 1, 1987Paper

Effects of temperature on cholinergic contractility of rabbit airway muscle

Journal of Applied Physiology
D L BrattonM M Grunstein

Abstract

To elucidate the mechanism underlying temperature-induced changes in airway cholinergic contractility, the effects of organ bath cooling were evaluated in isolated rabbit airway smooth muscle (ASM) segments isometrically contracted with methacholine (METH) (10(-8)-10(-3) M) and electrical field stimulation (ES), wherein the ES stimulus frequency was varied between 1 and 100 Hz. Cooling from 37 to 25 degrees C produced systematic increases (P less than 0.01) in isometric tension at various administered doses of METH and at different levels of ES. Since the potentiated contractions to ES significantly exceeded (P less than 0.001) the corresponding increases in METH-induced contractility, we evaluated whether the latter was attributed to temperature-mediated changes in intrinsic airway neuronal acetylcholine (ACh) release. Accordingly, the effects of ASM cooling were independently determined before and after inhibition of the Na+-K+ electrogenic pump with ouabain (10(-5) M), and depletion of intrinsic neuronal ACh stores with hemicholinium-3 (HC-3) (10(-3) M). In the presence of either ouabain or HC-3 the above responses to temperature reduction were reversed, and airway cooling was associated with abrupt relaxation of ASM segment...Continue Reading

Citations

Dec 17, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ying-Liang ChouHsing-Won Wang
Dec 29, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Li-Hsiang ChengHsing-Won Wang
Sep 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·G G Giesbrecht, M Younes
Oct 23, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Chuan-Hsiang KaoHsing-Won Wang
Apr 1, 2011·Allergy & Rhinology·Yuan-Yung LinHsing-Won Wang
Mar 3, 2015·Clinical and Experimental Otorhinolaryngology·Hsing-Won WangJia-Yi Wang
Nov 6, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Hsing-Won Wang, Chi-Chung Wu
Nov 15, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Li-Hsiang ChengHsing-Won Wang
Mar 26, 2013·Clinical and Experimental Otorhinolaryngology·Feng-Hsiang Chiu, Hsing-Won Wang
Jan 5, 2002·The Journal of General Physiology·Theodor V Burdyga, Susan Wray
Jan 1, 1992·Clinical and Experimental Pharmacology & Physiology·M P Rechtman
Apr 1, 1994·Pharmacology & Therapeutics·E R ChilversR A Challiss

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