PMID: 7370799May 26, 1980Paper

Effects of temperature on the decline in miniature end-plate potential frequency following a tetanus

Brain Research
H KitaW Van der Kloot

Abstract

When frog nerve-muscle preparations are stimulated tetanically in saline solutions containing Ca2+, Mn2+, Co2+, or Ni2+ there is a substantial rise in miniature end-plate potential (MEPP) frequency. After stimulation is ended, there is a decline back toward pre-stimulus MEPP frequencies. If we assume that MEPP frequencies are an index of the concentration of the divalent cations at some critical site in the nerve terminal, then the fall in MEPP frequency reflects the clearing of the divalent metal cation from the critical region. As a first step in investigating the clearing mechanism, we have studied the effects of temperature on the decline in MEPP frequencies following a tetanus. The Q10s for the fall in MEPP frequencies following the tetanus in Ca2+ or Mn2+ range between 1.2 and 1.6. The results can be interpreted in terms of a two-stage model for the fall-off in release probability following stimulation. In Co2+ or Ni2+ containing solutions at 7 degrees C or lower the MEPP frequency is sustained at an elevated level following the tetanus; at higher temperatures the decline does not reach the initial control level.

References

Jul 1, 1976·The Journal of Physiology·H Kita, W Van Der Kloot
Nov 1, 1975·Life Sciences·H E Statham, C J Duncan
Jan 1, 1976·Biophysical Journal·S W Provencher
Jan 1, 1972·Progress in Biophysics and Molecular Biology·P F Baker
Feb 1, 1973·British Journal of Pharmacology·R J Balnave, P W Gage
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·M BraunM Zimmermann
Nov 1, 1968·The Journal of Physiology·Z L BliochV A Nenashev
Nov 1, 1973·The Journal of Physiology·J N Weakly
Sep 28, 1971·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J HeuserR Miledi
Nov 5, 1974·Biochemistry·H Rottenberg, A Scarpa
Sep 12, 1973·Nature: New Biology·H Kita, W Van der Kloot
Sep 1, 1970·The Biochemical Journal·A L Lehninger
Apr 21, 1972·Science·U Meiri, R Rahamimoff
May 1, 1971·The Journal of Physiology·R S EisenbergP C Vaughan
Dec 1, 1965·The Journal of Physiology·B Katz, R Miledi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.