Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology

Chemistry Central Journal
Intan Soraya Che SulaimanMaznah Ismail

Abstract

Clinacanthus nutans Lindau is a well-known plant, native to tropical Asian countries. Reports on this plant that is rich in phenolic compounds have focused on its therapeutic anti-inflammatory, anti-herpes simplex, antioxidant, and anti-cancer characteristics. In this paper, the influence of the extraction parameters-temperatures (60-80 °C), times (80-120 min), and solvent ratios (70:30-90:10) of water:ethanol were investigated using response surface methodology in order to determine the optimum extraction conditions that could produce maximum extraction yields of the phenolic compounds and the highest anti-radical activity of the C. nutans extract. The optimum conditions suggested by the predicted model were: an extraction temperature of 60 °C, an extraction time of 120 min and a water:ethanol solvent ratio of 90:10 v/v%. The residual standard error of 0.2% indicated that there was no significant difference between the actual and predicted values and it proved that the models were adequate to predict the relevant responses. All the independent variables had a significant effect (p < 0.05) on all the responses which indicated that all extraction parameters employed in this study were important in the optimization process. The R...Continue Reading

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Citations

Jun 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aqilah Noor BahariSiti Efliza Ashari
Oct 23, 2020·Journal of Food Science and Technology·Ángel Félix Vargas-MadrizSalvador Horacio Guzmán-Maldonado
Jan 31, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Norsuhaili KamairudinDayang Radiah Awang Biak
Dec 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Irnia NurikaGuy C Barker

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