Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

Neuroscience Bulletin
Barbora FilovaJulius Hodosy

Abstract

Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats (GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed.

References

Apr 1, 1991·Trends in Pharmacological Sciences·B S McEwen
Aug 1, 1980·Pharmacology, Biochemistry, and Behavior·J Crawley, F K Goodwin
Jul 1, 1993·Frontiers in Neuroendocrinology·G E HoffmanJ G Verbalis
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·D M MinkinF van Haaren
Aug 1, 1996·The American Journal of Psychiatry·D R Rubinow, P J Schmidt
Jun 11, 1999·The American Journal of Physiology·L S Prince, M J Welsh
Nov 22, 2001·Hormones and Behavior·M A Morgan, D W Pfaff
Sep 28, 2002·Molecular Endocrinology·Cynthia A Heinlein, Chawnshang Chang
Oct 24, 2002·Current Opinion in Plant Biology·Manfred Heinlein
Dec 19, 2002·Hormones and Behavior·Jeremy L AikeyPeter J James
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Feb 24, 2004·Annual Review of Physiology·Adriana MaggiElisabetta Vegeto
May 28, 2005·Psychoneuroendocrinology·Alonso Fernández-Guasti, Lucía Martínez-Mota
Jun 21, 2005·Hormones and Behavior·Charlotte A CornilJacques Balthazart
Oct 1, 2005·Endocrinology·Jacques BalthazartGregory F Ball
Mar 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
May 9, 2006·Behavioural Brain Research·A EnnaceurP L Chazot
Oct 5, 2006·Endocrine Reviews·Nandini Vasudevan, Donald W Pfaff
Feb 6, 2007·Brain Research·Anita Nagypál, Ruth I Wood
Nov 7, 2007·Frontiers in Neuroendocrinology·Guido Michels, Uta C Hoppe
Dec 18, 2007·Frontiers in Neuroendocrinology·Nandini Vasudevan, Donald W Pfaff
Dec 21, 2007·Frontiers in Neuroendocrinology·C D ForadoriR J Handa
Apr 12, 2008·Hormones and Behavior·Sara SarkeyLydia L DonCarlos
Jul 8, 2008·Journal of Neuroendocrinology·K J Kovács
Oct 7, 2009·Physiology & Behavior·Alicia A Walf, Cheryl A Frye
May 2, 2012·Pharmacology, Biochemistry, and Behavior·Július HodosyPeter Celec
Jan 12, 2013·Cells, Tissues, Organs·Barbora FilováJúlius Hodosy

❮ Previous
Next ❯

Citations

Jan 20, 2016·Neuroscience Bulletin·Liu YangYu-Qiu Zhang
Jun 4, 2017·Hormones and Behavior·Emese DomonkosPeter Celec
May 10, 2016·Journal of Experimental Neuroscience·Olakunle J OnaolapoTaofeeq Omoleke
Jan 18, 2017·Clinical and Experimental Pharmacology & Physiology·Veronika BorbélyováJúlius Hodosy
Apr 29, 2018·Molecular Neurobiology·Birgit LudwigYogesh Dwivedi
Nov 18, 2016·Aging·Veronika BorbélyováPeter Celec
Aug 22, 2018·Frontiers in Endocrinology·Emese DomonkosPeter Celec
Oct 18, 2020·Human Reproduction Update·J PapeB Leeners

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.