PMID: 9429245Jan 16, 1998Paper

Effects of testosterone on fever and vasopressin mRNA in wether sheep given endotoxin

Research in Veterinary Science
R F Parrott, S V Vellucci

Abstract

This study investigated the effects of testosterone on the febrile response of castrated rams to immunological challenge. Core temperature was recorded by radiotelemetry in wethers (n = 6) injected with lipopolysaccharide endotoxin or saline before and after androgen treatment. The number of cells expressing vasopressin mRNA in the brain region implicated in the anti-pyretic response, the bed nucleus of the stria terminalis, was determined by in situ hybridisation histochemistry. Endotoxin, but not androgen, increased vasopressin message (P < 0.05), and androgen also did not alter basal or febrile temperatures. Hence, these preliminary findings question whether the androgen-dependent anti-pyretic mechanism described in the male rat is of physiological significance in the ram.

References

Apr 1, 1983·Canadian Journal of Physiology and Pharmacology·N W KastingR Bergland

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Citations

Sep 14, 2015·Neuroscience and Biobehavioral Reviews·David Chun-Hei PoonRaymond Chuen-Chung Chang

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