PMID: 107969Mar 23, 1979

Effects of tetracyclines on aldosterone- and insulin-mediated Na+ transport in the toad urinary bladder

Biochimica Et Biophysica Acta
M CoxI Singer


The effect of oxytetracycline and demethylchlortetracycline on aldosterone- and insulin-mediated Na+ transport (short-circuit current) were examined in toad urinary bladders mounted in modified Ussing chambers. Oxytetracycline had little or no effect on either basal or aldosterone-mediated Na+ transport. In contrast, demethylchlortetracycline markedly inhibited both basal and aldosterone-mediated Na+ transport. Furthermore, demethylchlortetracycline inhibited the aldosterone response significantly out of proportion to its effects on basal Na+ transport. Neither of the drugs had an effect on insulin-mediated Na+ transport. Consequently, the natriuresis observed in certain patients treated with demethylchlortetracyline may be related to drug-induced renal resistance to the effects of aldosterone.


Mar 25, 1978·British Medical Journal·D Zegers de BeylA de Troyer
Oct 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W N Scott, V S Sapirstein
Oct 18, 1974·Science·W B Benjamin, I Singer
Dec 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·I S EdelmanG A PORTER


May 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G L BradenM Cox
Jul 1, 1986·Drug Intelligence & Clinical Pharmacy·C I Miyagawa

Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Urinary Bladder
Bufo marinus
Demeclocycline, Calcium (1: 2) Salt
Oxytetracycline, (5 beta)-Isomer

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