Effects of tetrahydrocurcumin on hypoxia-inducible factor-1α and vascular endothelial growth factor expression in cervical cancer cell-induced angiogenesis in nude mice

BioMed Research International
Bhornprom YoysungnoenChatchawan Changtam

Abstract

Tetrahydrocurcumin (THC), one of the important in vivo metabolites of curcumin, inhibits tumor angiogenesis. Its effects on angiogenesis in cervical cancer- (CaSki-) implanted nude mice and its mechanisms on hypoxia-inducible factor-1α and vascular endothelial growth factor expression were investigated. Female BALB/c nude mice were divided into control (CON) and CaSki-implanted groups (CaSki group). One month after the injection with cervical cancer cells, mice were orally administered vehicle or 100, 300, and 500 mg/kg of THC daily for 30 consecutive days. The microvascular density (MVD) was evaluated using the CD31 expression. VEGF, VEGFR-2, and HIF-1α expression were also detected by immunohistochemistry. The MVD in CaSki + vehicle group was significantly increased compared to the CON + vehicle group. Interestingly, when treated with THC at all doses, the CaSki group showed a significant smaller number of the MVD. The CaSki + vehicle group also showed significantly increased VEGF, VEGFR-2, and HIF-1α expressions, but they were downregulated when mice were treated with THC at all doses. THC demonstrated an inhibitory effect against tumor angiogenesis in CaSki-implanted nude mice model. This effect is likely to be mediated by ...Continue Reading

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Citations

Feb 18, 2016·BioMed Research International·Bhornprom YoysungnoenSuthiluk Patumraj
Jul 23, 2011·Colloids and Surfaces. B, Biointerfaces·Anna KarewiczMaria Nowakowska
Nov 23, 2016·Critical Reviews in Food Science and Nutrition·Muhammad ImranHafiz Ansar Rasul Suleria
Aug 30, 2017·Food & Function·Xiao-Ping WangNa Chang
Sep 19, 2019·Journal of Complementary & Integrative Medicine·Luigi Della CorteSimone Garzon
Nov 15, 2019·Journal of Cancer Research and Clinical Oncology·Devarajan NaliniGanesan Senthil Kumar
Jun 4, 2020·Biomolecules·Ching-Shu LaiMin-Hsiung Pan
Nov 6, 2020·Journal of Ovarian Research·Mohammad Hossein PourhanifehHamed Mirzaei
Jan 1, 2021·International Journal of Molecular Sciences·Yu-Wen KaoKai-Chun Cheng
Aug 11, 2021·BioFactors·Xiao FuMasoud Najafi

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Methods Mentioned

BETA
xenografts

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