Effects of tetrodotoxin treatment in LGN on neuromodulatory receptor expression in developing visual cortex

Brain Research. Developmental Brain Research
Q GuM S Cynader

Abstract

The expression and distribution patterns of transmitter receptors change dramatically during pre- and post-natal development of the visual cortex, but the factors that control these processes are largely unknown. We have tested the hypothesis that input activity from the lateral geniculate nucleus (LGN), one major input source to visual cortex, may contribute to the processes underlying transmitter receptor redistributions in the visual cortex during development. We found that a short period of tetrodotoxin (TTX) treatment in LGN retarded the developmental expression and age-dependent reorganization of neuromodulatory receptors, including muscarinic, serotonergic and adrenergic receptors, in kitten primary visual cortex. The visual cortices ipsilateral to the TTX infusion site displayed a 'younger' receptor pattern than that of their contralateral control counterparts in the same animals. The results suggest that active input from LGN regulates the expression profile of a broad range of receptors in the developing visual cortex.

References

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Citations

Apr 7, 2000·Brain Research. Brain Research Reviews·B Roerig, M B Feller
Oct 24, 2000·Brain Research. Developmental Brain Research·D Echevarría, K Albus
Oct 3, 2003·Neurobiology of Learning and Memory·Qiang Gu
Jan 19, 2012·Nature Reviews. Neuroscience·Nicholas C Spitzer

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