Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring

Toxicological Sciences : an Official Journal of the Society of Toxicology
Steve K TeoAlan M Hoberman

Abstract

The present study determined effects of thalidomide on three successive generations of New Zealand White rabbits after oral dosing to F0 maternal rabbits during the later third of gestation (post major organogenesis) and lactation. One hundred and twenty four time-mated F0 rabbits (31/dose) were gavaged with 0, 30, 150, or 500 mg/kg thalidomide from gestation day 18 (DG 18) to lactation day 28 (DP or day postpartum 28) for approximately 42 days. At 6 months, 12 F1 males and 12 F1 females were randomly paired within each dose group and mated. Reproductive evaluation and/or gross necropsy of the thoracic, abdominal, and pelvic viscera was performed on day 29 postpartum (DP 29) for F0 rabbits, on DP 49 for F1 pups not selected for continued evaluation, after completion of mating for F1 rabbits, and on DG 29 for F1 rabbits on continued evaluation of F2 litter. There was no thalidomide-related mortality in F0 and F1 rabbits. One F0 doe at 30 and 150 mg/kg and 2 at 500 mg/kg aborted. Maternal F0 rabbits had reductions in feed consumption but not body weight gain during the gestation and lactation periods for 150 and 500 mg/kg. The numbers of does with stillborn and all pups dying from DP 1-4 was increased at 150 and 500 mg/kg. Mean n...Continue Reading

Citations

May 27, 2015·Toxicology and Applied Pharmacology·Xiugong GaoJeffrey J Yourick
Jul 4, 2008·Reproductive Toxicology·Keith Robinson
Dec 22, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jan L Reichard-BrownKatherine McBride
Oct 30, 2016·Reproductive Toxicology·Fernanda Sales Luiz ViannaLavínia Schuler-Faccini
Nov 9, 2016·Acta Odontologica Scandinavica·Jiao WeiQianming Chen
Jun 16, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Mildred S ChristianLouise Latriano
Mar 6, 2012·Bioanalytical Reviews·Beate StrehlitzRegina Stoltenburg
Dec 12, 2018·Advanced Biosystems·Jennifer Rico-VarelaLeo Q Wan

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