Effects of THC on behavioral measures of impulsivity in humans

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Jennifer McDonaldHarriet de Wit

Abstract

This study investigated the acute effects of delta(9)-tetrahydrocannabinol (THC) on four behavioral measures of impulsivity in recreational marijuana users. Although impulsive behavior has been studied using several different measures of impulsivity, few studies have utilized more than one of these measures on a single cohort. In this study, 37 healthy men and women participated in three sessions, in which they received capsules containing placebo, 7.5, or 15 mg THC in randomized order under double-blind conditions. Subjects were tested on the following four tasks: the Stop task, which measures the ability to inhibit a prepotent motor response; a Go/no-go task; a Delay discounting task, which measures the value of delayed or uncertain reinforcers; and a time estimation task, which measures alterations in time perception through a time reproduction procedure. Subjects also completed mood questionnaires and general measures of performance. THC produced its expected effects on subjective measures including increases in ARCI euphoria and marijuana scales. THC increased impulsive responding on the Stop task but did not affect performance on either the Go/no-go or Delay or Probability discounting tasks. On the time reproduction task,...Continue Reading

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Citations

Jan 21, 2006·Psychopharmacology·Boris B QuednowMichael Wagner
Jul 5, 2008·Psychopharmacology·Jennifer L Perry, Marilyn E Carroll
Jun 17, 2009·Psychopharmacology·Dagmar KoetheF Markus Leweke
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