Effects of the 5-HT2C receptor agonist Ro60-0175 and the 5-HT2A receptor antagonist M100907 on nicotine self-administration and reinstatement

Neuropharmacology
Paul J FletcherGuy A Higgins

Abstract

The reinforcing effects of nicotine are mediated in part by brain dopamine systems. Serotonin, acting via 5-HT(2A) and 5-HT(2C) receptors, modulates dopamine function. In these experiments we examined the effects of the 5-HT(2C) receptor agonist Ro60-0175 and the 5-HT(2A) receptor antagonist (M100907, volinanserin) on nicotine self-administration and reinstatement of nicotine-seeking. Male Long-Evans rats self-administered nicotine (0.03 mg/kg/infusion, IV) on either a FR5 or a progressive ratio schedule of reinforcement. Ro60-0175 reduced responding for nicotine on both schedules. While Ro60-0175 also reduced responding for food reinforcement, response rates under drug treatment were several-fold higher than in animals responding for nicotine. M100907 did not alter responding for nicotine, or food, on either schedule. In tests of reinstatement of nicotine-seeking, rats were first trained to lever press for IV infusions of nicotine; each infusion was also accompanied by a compound cue consisting of a light and tone. This response was then extinguished over multiple sessions. Injecting rats with a nicotine prime (0.15 mg/kg) reinstated responding; reinstatement was also observed when responses were accompanied by the nicotine as...Continue Reading

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Citations

Sep 18, 2013·Trends in Pharmacological Sciences·Guy A HigginsPaul J Fletcher
Oct 2, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dympna HarmeyPaul J Kenny
Dec 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Abigail G SchindlerCharles Chavkin
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Jan 22, 2017·ACS Chemical Neuroscience·Harshini NeelakantanKathryn A Cunningham
Nov 25, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lourdes Valencia-TorresLora K Heisler
Mar 29, 2018·Journal of Psychopharmacology·Susana Barbosa-Méndez, Alberto Salazar-Juárez
Oct 27, 2017·Journal of Psychopharmacology·Guy A HigginsPaul J Fletcher
Dec 9, 2017·The Journal of Pharmacology and Experimental Therapeutics·Brenda M GannonGregory T Collins
Nov 10, 2013·PloS One·Carolina Costola-de-SouzaJoão Palermo-Neto
Dec 26, 2018·Frontiers in Pharmacology·Amanda E PriceKathryn A Cunningham
Mar 19, 2020·International Journal of Molecular Sciences·Cristiano BombardiGiuseppe Di Giovanni
Dec 29, 2016·Psychopharmacology·Adriaan W Bruijnzeel
Dec 17, 2017·Neuropharmacology·Gregory T CollinsCharles P France
May 6, 2021·International Journal of Molecular Sciences·Cristiano BombardiGiuseppe Di Giovanni
Apr 15, 2015·ACS Chemical Neuroscience·Guy A Higgins, Paul J Fletcher
Nov 8, 2017·ACS Chemical Neuroscience·Claudia A SotoNoelle C Anastasio
Mar 1, 2019·Molecular Neuropsychiatry·Heath D SchmidtNii A Addy

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