Abstract
Seven-valent pneumococcal conjugate vaccine (PCV7) provides protection against invasive pneumococcal disease that extends to unvaccinated populations, such as elderly or immunocompromised adults. PCV7 also reduces incidence of pneumococcal penicillin resistance. In this study, the potential impact of PCV7 on pneumococcal fluoroquinolone resistance was examined. U.S. levofloxacin-resistant isolates (264) from TRUST surveillance studies (1999-2004) were serotyped and quinolone resistance-determining region of parC/E and gyrA/B sequenced. Changes in prevalence of vaccine/nonvaccine serotypes during 2000-2004 and 1999-2004 were analyzed by regression analyses and chi-square trend test. The introduction of PCV7 (2000-2004) did not affect fluoroquinolone resistance prevalence, but mutants with vaccine serotypes declined linearly at -6.6 +/- 0.8% per year (p = 0.003), with concomitant replacement by nonvaccine serotypes; vaccine-related serotypes (6A, 9N, 19A, and 23N) increased (p = 0.04). Differential selection between vaccine and nonvaccine serotypes occurred for mutants containing amino acid substitutions at either ParC Ser79 (p = 0.01) or both ParC Ser79 and GyrA Ser81 (p = 0.04). Among mutants with ParC Ser79 substitutions, vacc...Continue Reading
References
Oct 1, 1992·Antimicrobial Agents and Chemotherapy·L K McDougalF C Tenover
Aug 1, 1991·The Journal of Infectious Diseases·R MuñozB G Spratt
Dec 1, 1983·The Journal of Infectious Diseases·J B RobbinsR H Tiesjema
Oct 1, 1996·Antimicrobial Agents and Chemotherapy·X S PanL M Fisher
May 26, 1999·Emerging Infectious Diseases·M Lipsitch
Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W P HausdorffG R Siber
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J G BartlettM J Fine
Apr 13, 2001·JAMA : the Journal of the American Medical Association·K A RobinsonUNKNOWN Active Bacterial Core Surveillance (ABCs)/Emerging Infections Program Network
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·M S NiedermanUNKNOWN American Thoracic Society
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Todd A DaviesRaul Goldschmidt
Jul 3, 2003·The Journal of Antimicrobial Chemotherapy·Todd A DaviesAlan Evangelista
Jul 5, 2003·Lancet·Reinier VeenhovenElisabeth Sanders
Aug 2, 2003·Emerging Infectious Diseases·Sue LimDonald E Low
Aug 2, 2003·Emerging Infectious Diseases·Mina Ebrahimi-RadBrigitte Gicquel
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
Jun 9, 2004·Lancet·D BogaertP W M Hermans
Aug 12, 2004·JAMA : the Journal of the American Medical Association·Gili Regev-YochayEthan Rubinstein
Nov 17, 2004·The Pediatric Infectious Disease Journal·Stephen I PeltonColin D Marchant
Feb 1, 2005·The Lancet Infectious Diseases·William P HausdorffKeith P Klugman
Mar 9, 2005·Lancet·David S StephensUNKNOWN Georgia Emerging Infections Program
Jun 21, 2005·Emerging Infectious Diseases·Crystal N JohnsonKen B Waites
Oct 27, 2005·JAMA : the Journal of the American Medical Association·Catherine A LexauUNKNOWN Active Bacterial Core Surveillance Team
Nov 4, 2005·The Journal of Infectious Diseases·Rekha PaiUNKNOWN Active Bacterial Core Surveillance Team
Apr 7, 2006·The New England Journal of Medicine·Moe H KyawUNKNOWN Active Bacterial Core Surveillance of the Emerging Infections Program Network
May 3, 2006·The Journal of Infectious Diseases·Laura L HammittThomas W Hennessy
Nov 23, 2006·Antimicrobial Agents and Chemotherapy·Daniel E RozenKeith P Klugman
Citations
Jun 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer B RosenUNKNOWN CDC Emerging Infections Program Network
Feb 17, 2009·The Journal of Antimicrobial Chemotherapy·P L HoK H Chow
Sep 14, 2011·Antimicrobial Agents and Chemotherapy·Jeffrey FernandezA Simon Lynch
Feb 24, 2010·Antimicrobial Agents and Chemotherapy·Brian J MorrowKaren Bush
Feb 15, 2012·Vaccine·Jae-Hoon SongBernard Fritzell
Mar 4, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MatthijnssensUNKNOWN RotaBel study group
Jun 14, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yu-Hua Ma, Gui-Sheng Ye
Feb 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ravinder KaurMichael E Pichichero
Jun 22, 2010·Molecular Biology Reports·Qiao ZhangChangzheng Wang