Effects of the active neurosteroid allotetrahydrodeoxycorticosterone on long-term potentiation in the rat hippocampus: implications for depression

Progress in Neuro-psychopharmacology & Biological Psychiatry
Bernardo DubrovskyJohn Harris

Abstract

We studied the effects of the active neurosteroid (ANS) allotetrahydrodeoxy corticosterone (ATHDOC) on long-term potentiation (LTP) in the dentate gyrus (DG) of intact, urethane anesthetized rats. Intravenous injection of the hormone at two doses, 0.1 and 0.5 mg/kg, produced a significant decrease in both components of the response: excitatory postsynaptic potentials (EPSP) and population spikes (PS). The effects were similar for the two doses. The results are discussed in terms of the potential mechanism by which ATHDOC modulates neural processes associated with symptoms present in depression syndromes.

References

May 1, 1974·Psychological Medicine·W A Lishman
Feb 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·S I Cohen
Mar 1, 1993·Behavioral and Neural Biology·G MassicotteM Ohayon
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·D P UzunovA Guidotti
Jul 11, 1998·The American Journal of Psychiatry·E RomeoR Rupprecht
Dec 13, 2000·Brain Research. Molecular Brain Research·P FollesaG Biggio
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jens M Langosch, Jörg Walden
Nov 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Frank PadbergRainer Rupprecht
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cornelius SchüleRainer Rupprecht

❮ Previous
Next ❯

Citations

Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bernardo O Dubrovsky
Sep 12, 2006·Pharmacology, Biochemistry, and Behavior·Bernardo Dubrovsky
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jon H Kaas
Dec 1, 2010·Hormone Molecular Biology and Clinical Investigation·Alejandro F De NicolaLuis Miguel Garcia-Segura
Aug 3, 2021·Journal of Neuroendocrinology·Torbjörn BäckströmMarie Bixo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.