Effects of the addition of methyltestosterone to combined hormone therapy with estrogens and progestogens on sexual energy and on orgasm in postmenopausal women

Climacteric : the Journal of the International Menopause Society
S R Lenharo PenteadoE C Baracat

Abstract

To evaluate the effect of the addition of methyltestosterone to estrogen and progestogen therapy on postmenopausal sexual energy and orgasm. Sixty postmenopausal women in a stable relationship with a partner capable of intercourse, and presenting sexual complaints that appeared after menopause, were randomly divided into two groups: EP (n = 29) received one tablet of equine estrogens (CEE) 0.625 mg plus medroxyprogesterone acetate (MPA) 2.5 mg and one capsule of placebo; EP + A (n = 31) received one tablet of CEE 0.625 mg plus MPA 2.5 mg and one capsule of methyltestosterone 2.0 mg; The treatment period was 12 months. The effects of treatment on sexual energy were assessed using the Sexual Energy Change Scale. The ability to reach orgasm in sexual relations with the partner was verified through monthly calendars and by calculating the ratio between monthly frequency of orgasms in sexual relations and monthly sexual frequency. There was a significant relationship between improvement in level of sexual energy and the addition of methyltestosterone to CEE/MPA treatment (p = 0.021). No significant effect on orgasmic capacity was noted after the treatment period. Addition of methyltestosterone to CEE/MPA therapy may increase sexual ...Continue Reading

References

Feb 1, 1991·The Journal of Clinical Endocrinology and Metabolism·B B Sherwin
Jul 1, 1987·Psychosomatic Medicine·B B Sherwin, M M Gelfand
Apr 1, 1980·Clinical Endocrinology·J BancroftG Tyrer
Jan 16, 1995·The American Journal of Medicine·R Sands, J Studd
Feb 1, 1997·Journal of Pediatric and Adolescent Gynecology·S C MatsonG J McGrath
Nov 26, 1999·Clinical Obstetrics and Gynecology·K M Hoeger, D S Guzick
Mar 1, 2000·Journal of Women's Health & Gender-based Medicine·M M Gelfand
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Adrian S DobsCarla P Roberts
Nov 1, 2002·Current Opinion in Urology·Aristotelis G AnastasiadisRidwan Shabsigh
Mar 25, 2004·JAMA : the Journal of the American Medical Association·Miriam KuppermannUNKNOWN Ms Research Group
Apr 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephen N BirrellWayne D Tilley

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Citations

May 29, 2009·The Journal of Sexual Medicine·Rachel HessKaren A Matthews
Jun 30, 2010·The Journal of Sexual Medicine·Waguih William IshakYekaterina Bakhta
Dec 30, 2008·Maturitas·Melquíades PereiraEdmund C Baracat
Jun 6, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vicente Renato BagnoliEdmund Chada Baracat
Dec 1, 2010·Einstein·Jucilene Sales da Paixão SilvaEdmund Chada Baracat
Oct 20, 2005·The Cochrane Database of Systematic Reviews·W SomboonpornR Bell
Jun 17, 2008·Climacteric : the Journal of the International Menopause Society·H J T Coelingh BenninkE Diczfalusy
Sep 1, 2012·Expert Review of Endocrinology & Metabolism·Marie LebbeWiebke Arlt

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