PMID: 2484574Dec 1, 1988Paper

Effects of the administration of cadmium and zinc on the concentration of zinc in the thymus of rats

Biological Trace Element Research
P HuertaJ M Teijon

Abstract

The zinc content of thymus glands of male Wistar rats has been determined during five weeks of treatment with ZnCl2 and CdCl2, and compared with a group of control rats. Thymus gland extracts were chromatographed on columns of Sephadex G-75 and the zinc content of the one hundred fractions obtained were determined by atomic absorption spectrophotometry. The rats treated with ZnCl2 showed an increase in the thymus concentration of zinc bound to high and low molecular weight proteins. The rats treated with CdCl2 showed an increase in zinc concentration, as opposed to the control group, during the first three weeks of treatment, and thereafter show a toxic effect of cadmium on the gland, with ulterior regression of the latter, and a decrease in the concentration of zinc.

References

Sep 1, 1976·Toxicology and Applied Pharmacology·A P Leber, T S Miya
Feb 1, 1985·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·R W Olafson
Feb 1, 1974·Quarterly Reviews of Biophysics·I Bremner
Feb 15, 1974·FEBS Letters·R H Bühler, J H Kägi
Sep 10, 1970·Biochemical and Biophysical Research Communications·G W EvansW E Cornatzer
Apr 1, 1967·Journal of Chronic Diseases·H A SchroederJ J Balassa
Jun 15, 1980·Toxicology and Applied Pharmacology·M Sato, Y Nagai

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Citations

Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M G CifoneA Santoni

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