Effects of the aluminium speciation on the morphology of rabbit erythrocytes: a toxicological model

Toxicology in Vitro : an International Journal Published in Association with BIBRA
P ZattaP Zambenedetti

Abstract

The great majority of papers dealing with aluminium (Al) experimental toxicology in vivo and/or in vitro, do not consider the relevance of the metal chemical speciation as a conditio sine qua non to a correct interpretation of aluminium toxicological data. In fact, different aluminium compounds such as salts, stable, metastable, lipophilic or hydrophilic complexes with different thermodynamics and kinetics properties are indifferently utilized by most laboratories. In this connection, the molecular bases that explain Al toxicity are largely uninterpretable. The aim of this study, therefore, is to demonstrate how relevant is the issue of aluminium speciation to the understanding of the toxic properties of the metal ion. In our experimentation we used, as a heuristic model, rabbit erythrocytes (RBC) (Sheetz and Singer, 1974), because these animals are well known for their sensitivity to Al intoxication (Wisniewski and Sturman, 1989). Results reported herein show how the metal chemical speciation can paradigmatically modify the RBC morphology in a metal speciation-dependent manner. Finally, a new toxicological protocol that, by simplifying the methodology of aluminium solution preparation, could standardize the study of aluminium ...Continue Reading

References

Nov 1, 1986·Neurobiology of Aging
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M P Sheetz, S J Singer
Jan 1, 1981·Journal of Nutritional Science and Vitaminology·T Matsui, S Kitaoka
Jun 1, 1994·Journal of Inorganic Biochemistry·C ExleyJ D Birchall
Jul 1, 1994·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·P ZambenedettiP F Zatta
Aug 30, 1996·Journal of Toxicology and Environmental Health·W R HarrisP F Zatta
Mar 1, 1990·Environmental Geochemistry and Health·H M WisniewskiJ W Shek

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Citations

Jul 24, 2012·Ecotoxicology and Environmental Safety·Sunandan PakrashiAmitava Mukherjee
Dec 3, 2014·International Journal of Environmental Research and Public Health·Natacha M M da CostaRafael Rodrigues Lima
Oct 19, 2000·Journal of Biomechanical Engineering·S D ChambersS L Ceccio

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