Effects of the anaphylatoxin, C5a, on renal and glomerular hemodynamics in the rat

Kidney International
J C PelayoR C Blantz

Abstract

The effects of intrarenal infusion of the complement-derived anaphylatoxin, C5a, upon glomerular hemodynamics were examined in the Munich-Wistar rat, a strain with glomeruli on the kidney surface. Human C5a (1.5 micrograms/min) or vehicle was infused into the left renal artery for 12 min, and glomerular capillary (PG) and Bowman's space pressures, nephron plasma flow (SNPF) afferent and efferent arteriolar protein concentrations, nephron filtration rate (SNGFR) and the glomerular ultrafiltration coefficient (LpA) determined. Human C5a infusion resulted in a reduction in SNPF due to increased efferent arteriolar resistance, and PG increased which maintained SNGFR constant. LpA was numerically lower but not significantly decreased. Infusion of porcine C5ades Arg decreased glomerular filtration rate and renal blood flow. No polymorphonuclear leukocytes were observed within glomerular capillaries of C5a infused rats, and rat leukocytes did not exhibit receptors for human C5a infused. Renal artery infusion of either human C5a or porcine C5a resulted in renal hemodynamic alterations and, as documented for human C5a, effects of C5a upon renal vascular resistance can be added to the known effect of C5a on the polymorphonuclear leukocyte.

References

Oct 1, 1976·The Journal of Clinical Investigation·R C Blantz, C B Wilson
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D E Chenoweth, T E Hugli
Feb 1, 1968·The Journal of Experimental Medicine·C G Cochrane, H J Müller-Eberhard
Dec 1, 1983·The Journal of Clinical Investigation·G C GroggelD J Salant
Dec 4, 1981·Molecular and Cellular Biochemistry·T E HugliS Russell
Nov 1, 1981·Kidney International·C B WilsonR C Blantz
Dec 1, 1980·The Journal of Clinical Investigation·D J SalantW G Couser
Jul 1, 1965·The Journal of Experimental Medicine·C G COCHRANEF J DIXON

❮ Previous
Next ❯

Citations

Oct 1, 1987·Immunopharmacology·F MarceauT E Hugli
May 1, 1994·European Journal of Clinical Investigation·K SchlottmannM Steinhausen
Apr 1, 1989·Kidney International·D J SalantA V Cybulsky
Nov 1, 1990·Kidney International·M SteinhausenD L Wiegman
Sep 1, 1988·Kidney International·J W FriesH G Rennke
Sep 1, 1990·Kidney International·V TimmermansM A Pawlak
Jan 1, 1992·Renal Failure·L De NicolaR C Blantz
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Sriram S NarsipurRoland C Blantz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.