PMID: 11605944Oct 19, 2001Paper

Effects of the anesthetic gases xenon, halothane, and isoflurane on calcium and potassium currents in human atrial cardiomyocytes

Anesthesiology
R HünekeA Lückhoff

Abstract

Negative inotropic and proarrhythmic side effects on the heart are well known for the volatile anesthetics halothane and isoflurane but not for the noble gas xenon. We investigated the effects of halothane, isoflurane, and xenon on calcium and potassium currents in human atrial myocytes to elucidate the cellular and molecular basis of their cardiac actions. Atrial myocytes were prepared from the right auricles obtained from patients undergoing heart surgery. Ion currents were measured with the whole cell patch clamp technique during superfusion of the cells with solutions that contained halothane, isoflurane, or xenon at concentrations corresponding to their respective minimum alveolar concentration (MAC); gas concentrations were determined with the head space-gas chromatography/mass spectrometry/selected ion monitoring method. L-type calcium currents were significantly depressed by 31.9 +/- 4.1%, from -1.8 +/- 0.3 to -1.2 +/- 0.4 picoampere (pA)/picofarad (pF) (n = 4; P < 0.05) at 1 MAC halothane and by 21.7 +/- 9.2%, from -1.6 +/- 0.7 to -1.2 +/- 0.6 pA/pF (n = 7; P < 0.05) at 1 MAC isoflurane, but not affected by 70% xenon (1 MAC). Inwardly rectifying potassium currents were not influenced by any anesthetic. Halothane (1 MAC...Continue Reading

References

Apr 1, 1989·Acta Anaesthesiologica Scandinavica·K HirotaY Momose
Mar 1, 1970·The Journal of Physiology·G W Beeler, H Reuter
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Feb 1, 1984·Circulation Research·I R JosephsonA M Brown
Feb 17, 1994·Nature·N P Franks, W R Lieb
Jul 1, 1995·Cardiovascular Research·L Firek, W R Giles
Jun 1, 1997·The Journal of Clinical Investigation·M Rivet-BastideR Fischmeister
Jun 30, 1998·Pflügers Archiv : European journal of physiology·P SchafferB Koidl
Dec 9, 1998·Nature·N P FranksW R Lieb
Sep 4, 1999·Circulation Research·D R Van WagonerJ M Nerbonne
Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·M D Krasowski, N L Harrison
Oct 26, 1999·Cardiovascular Research·D J Snyders
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·C BoixelS N Hatem
Mar 29, 2000·Anesthesia and Analgesia·A StadnickaW M Kwok
Sep 19, 2000·British Journal of Pharmacology·L A DaviesS M Harrison

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Citations

Apr 3, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Takahisa Goto
May 23, 2003·The New England Journal of Medicine·Jason A CampagnaStuart A Forman
Jun 18, 2010·Journal of Cardiovascular Pharmacology·Albert DunninkMarc A Vos
Aug 31, 2004·Anesthesia and Analgesia·Maike A Grosse HartlageThomas P Weber
Jul 24, 2004·Anesthesia and Analgesia·Heikki SwanLauri Toivonen
Oct 27, 2004·Anesthesia and Analgesia·Oliver KunitzRolf Rossaint
Jan 28, 2005·Anesthesia and Analgesia·Takahiro SuzukiTakashi Mashimo
Oct 26, 2007·Anesthesia and Analgesia·Jan-H BaumertRolf Rossaint
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Benedikt Preckel, Jens Bolten
Jul 15, 2005·Best Practice & Research. Clinical Anaesthesiology·Benedikt Preckel, Wolfgang Schlack
Jul 30, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·O DelhayeB Vallet
May 27, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Paul S Pagel
Nov 23, 2007·European Journal of Pharmacology·Dai IshiwaTomio Andoh
Jun 16, 2005·Acta Anaesthesiologica Scandinavica·J-H BaumertR Rossaint
Apr 23, 2004·Acta Anaesthesiologica Scandinavica·R HünekeA Lückhoff
Aug 15, 2006·Journal of Clinical Anesthesia·Shunji KobayashiShigehito Sato
Jul 16, 2008·Laboratory Animals·Roland C E FrancisWillehad Boemke
Mar 18, 2008·British Journal of Anaesthesia·J-H BaumertR Rossaint
May 10, 2002·Journal of Cardiovascular Pharmacology and Therapeutics·Shengmei ZhouPeng-Sheng Chen
Oct 18, 2005·European Journal of Anaesthesiology·M CoburnR Rossaint
Apr 18, 2019·Seminars in Cardiothoracic and Vascular Anesthesia·Paola Elvira MocaveroAntonio Corcione
Sep 27, 2008·Journal of Applied Physiology·Dominic P D'AgostinoJay B Dean
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Akira KitamuraToshio Narahashi
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Srinivas M TipparajuMary B Wagner
Oct 24, 2019·Clinical and Experimental Pharmacology & Physiology·Julliane V Joviano-SantosAnderson J Ferreira

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