Effects of the angiotensin II receptor blockers telmisartan versus valsartan in combination with hydrochlorothiazide: a large, confirmatory trial

Blood Pressure Monitoring
William B WhiteRobert Guthrie

Abstract

In 2004-2005, the antihypertensive effects of telmisartan 80 mg versus valsartan 160 mg combined with hydrochlorothiazide 25 mg were assessed in a large placebo-controlled trial in patients with stages 1 and 2 hypertension and demonstrated that both agents were highly effective in lowering blood pressure (BP) compared with placebo and that telmisartan lowered BP significantly greater than valsartan. To confirm this finding according to Food and Drug Administration guidelines, we performed a second large trial using the same design in an entirely separate patient population. The trial was double-blind with a 4 : 4 : 1 randomization scheme to compare once daily telmisartan 80 mg plus hydrochlorothiazide 25 mg versus once daily valsartan 160 mg plus hydrochlorothiazide 25 mg versus once daily placebo on reductions in seated clinic BP in patients with stages 1 and 2 hypertension. The primary endpoints were the changes from baseline in seated diastolic and systolic BP at the end of the 8-week treatment period. Safety endpoints included adverse events, changes in laboratory parameters and pulse rate. In total, 1185 patients were randomized (of which 1181 were treated and included in the primary analysis: 528 in the telmisartan-hydroc...Continue Reading

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Citations

Jan 25, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hisato TakagiUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Dec 2, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi MorimotoKatsunori Sawada
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May 8, 2010·Vascular Health and Risk Management·Domenico GalzeranoCarlo Gaudio
Aug 17, 2012·Expert Review of Cardiovascular Therapy·Benjamin J EpsteinNiren K Shah
Aug 17, 2010·Expert Opinion on Pharmacotherapy·Lars Christian Rump, Lorenz Sellin
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Dec 4, 2012·International Journal of Cardiology·Hisato TakagiUNKNOWN All-Literature Investigation of Cardiovascular Evidence Group
May 2, 2018·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Swenja SurminskiDavid Proverbs

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