Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes

International Journal of Pharmaceutics
Alejandro TorrecillasJuan C Gómez-Fernández

Abstract

The effect of 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-18-OCH(3), edelfosine), and six other analog asymmetric phosholipids on the physical properties of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) model membranes was studied using differential scanning calorimetry (DSC), (31)P-nuclear magnetic resonance ((31)P NMR) and X-ray diffraction. DSC data revealed that, at concentrations of 40mol% and higher, a new type of mixtures with higher T(c) and narrower transitions appeared with all the asymmetric lipids studied. At very high concentrations of these lipids (50-80 mol%), destabilization was observed in the systems probably because of the formation of micelles or small vesicles. In all cases, the asymmetric lipids at concentrations of 40 mol% induced the formation of interdigitated structures in the lamellar gel phase, as deduced from X-ray diffraction. The asymmetric phospholipids were also added to 1,2-dielaidoyl-sn-glycero-3-phosphoethanolamine (DEPE) model membranes and DSC data revealed that the lipids primarily affected transition from the lamellar gel (L(beta)) to the lamellar liquid crystalline (L(alpha)) phase in two aspects: the transition temperature was reduced, and the transition itself became ...Continue Reading

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Citations

Feb 22, 2012·PloS One·Lars KuerschnerChristoph Thiele
Jun 10, 2016·The Journal of Physical Chemistry. B·Kleopatra EleftheriouDimitris Tsiourvas
Jun 18, 2011·Pharmacogenetics and Genomics·Geo SeminiKerstin Danker
Aug 21, 2008·The Journal of Physical Chemistry. B·Alessio AusiliJuan C Gómez-Fernández
Jun 21, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Alessio AusiliJuan C Gómez Fernández

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