Effects of the antiandrogens, vinclozolin and cyproterone acetate on gonadal development in the Japanese medaka (Oryzias latipes)

Aquatic Toxicology
Yiannis KiparissisChris D Metcalfe

Abstract

This study was focused on determining the effects of exposure to antiandrogens on the gonadal development of Japanese medaka (Oryzias latipes). Test compounds included the fungicide, vinclozolin and the clinical antiandrogen, cyproterone acetate. Newly hatched medaka were exposed to aqueous solutions of vinclozolin (2500 microg/l) and the vinclozolin fungicide formulation, Ronilan (1000 and 5000 microg/l) and cyproterone acetate (1 and 10 microg/l), for 3 months. Histological evaluation of the gonadal tissues of exposed fish indicated that the 5000 microg/l concentration of the vinclozolin formulation (Ronilan) induced a low incidence of intersex (i.e. testis-ova) and the 2500 microg/l concentration of vinclozolin-affected spermatogenesis in males. Also, the vinclozolin treatments induced moderate ovarian atresia. Cyproterone acetate also induced a low incidence of testis-ova, but in contrast to the vinclozolin treatment the amount of ovarian tissue in the testis-ova was equal to or greater than the amount of testicular tissue. In the cyproterone acetate treatments, both oogenesis and spermatogenesis were moderately inhibited at all test concentrations. The results of this study indicate that antiandrogens have the potential to...Continue Reading

References

May 1, 1975·General and Comparative Endocrinology·R K Rastogi, G Chieffi
Mar 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·W R Kelce, E M Wilson
Dec 10, 1998·The Journal of Endocrinology·P Sohoni, J P Sumpter
Feb 17, 2000·Trends in Endocrinology and Metabolism : TEM·J K Amory, W J Bremner
Oct 3, 2000·Zygote : the Biology of Gametes and Early Embryos·L Di MatteoS Minucci
Apr 18, 2001·The Science of the Total Environment·L ViganòA Mandich
Jul 17, 2001·The Science of the Total Environment·S Y Euling, C A Kimmel
Jul 20, 2001·Marine Environmental Research·J C HarshbargerM Y Young
Jan 1, 1962·General and Comparative Endocrinology·T YAMAMOTO

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Citations

Dec 23, 2006·Environmental Health Perspectives·Caroline Cox, Michael Surgan
Aug 5, 2014·Aquatic Toxicology·Denise FernandesCinta Porte
Nov 19, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Carlie A LaLoneGerald T Ankley
Jul 24, 2012·Aquatic Toxicology·Azadeh HatefOtomar Linhart
Mar 6, 2010·Aquatic Toxicology·Allen W OlmsteadSigmund J Degitz
Jun 30, 2015·Environmental Toxicology and Chemistry·Karin L KinnbergHenrik Holbech
Jul 5, 2015·Theriogenology·Malgorzata KnetMalgorzata Duda
Jul 21, 2009·Environmental Pollution·Jean-Philippe Besse, Jeanne Garric
Apr 26, 2015·General and Comparative Endocrinology·Michael R LeeKenneth Oliveira
Jun 24, 2004·Mechanisms of Development·Akihiro Shima, Hiroshi Mitani
Sep 22, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jian LiZijian Wang
Jul 28, 2016·Journal of Applied Toxicology : JAT·Yoshifumi HorieNorihisa Tatarazako
Aug 19, 2008·Toxicology and Applied Pharmacology·José-Manuel Molina-MolinaPatrick Balaguer
Apr 22, 2010·Bulletin of Environmental Contamination and Toxicology·Jian LiXianzhi Peng
Feb 8, 2020·Environmental Toxicology and Chemistry·Margaret E McArdleAudrey J Bone
Apr 8, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timo HamersAbraham Brouwer
Sep 15, 2017·Environmental Science and Pollution Research International·Eric GismondiCélia Joaquim-Justo
Mar 23, 2021·Bulletin of Environmental Contamination and Toxicology·Wenting SongShuangying Hao

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