Effects of the Antidepressant Fluoxetine on the Somatostatin Interneurons in the Basolateral Amygdala

Neuroscience
Héctor CarcellerRamón Guirado

Abstract

Although the precise mechanism of action of antidepressant drugs remains elusive, the neuroplastic hypothesis has gained acceptance during the last two decades. Several studies have shown that treatment with antidepressants such as Fluoxetine is associated with enhanced plasticity in control animals, especially in regions such as the visual cortex, the hippocampus and the medial prefrontal cortex. More recently, the basolateral amygdala has been shown to be affected by Fluoxetine leading to a reopening of critical period-like plasticity in the fear and aggression circuits. One of the key elements triggering this type of brain plasticity are inhibitory networks, especially parvalbumin interneurons. However, recent work on fast-acting antidepressants has shown also an important role for somatostatin interneurons. Here we show that Fluoxetine reorganizes inhibitory circuits through increased expression of the plasticity-related molecule PSA-NCAM which regulates interneuronal structure and connectivity. In addition, we demonstrate that treatment with this antidepressant alters the structure of somatostatin interneurons both at the level of dendritic spines and of axonal en passant boutons. Our findings suggest that new strategies t...Continue Reading

Citations

Dec 12, 2019·European Eating Disorders Review : the Journal of the Eating Disorders Association·Lea ThalerHoward Steiger
Jul 14, 2020·Frontiers in Cellular Neuroscience·Antonio BrunoGeorgia Mandolesi
Jul 25, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Raul Chavez-ValdezLee J Martin
Feb 7, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Lu LuJeffrey R Strawn
Jan 30, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nikita van der VinneMartijn Arns
Jun 1, 2021·Biological Psychiatry·Eero Castrén, Lisa M Monteggia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.