Effects of the antipsychotic drug sulpiride on reproductive hormones in healthy men: relationship with body weight regulation

Pharmacopsychiatry
T BaptistaL Hernandez

Abstract

Metabolic and endocrine abnormalities secondary to hyperprolactinemia, particularly hypogonadism, may be involved in the excessive body weight gain observed during treatment with antipsychotic drugs. The present study was conducted in healthy men in order to detect an endocrine imbalance secondary to antipsychotic drug administration, which, if sustained in the long term, might be involved in the development of obesity. Sulpiride (200 mg daily for 30 days) or placebo was nonblindly administered, and body weight gain was correlated with the serum levels of prolactin, luteinizing hormone, follicle-stimulating hormone, estradiol, free testosterone, thyrotropic hormone, free tetraiodothyroxine, cortisol, dehydroepiandrosterone sulphate (DHEA-S), and the ratios estradiol/testosterone and testosterone/DHEA-S; the blood lipids were also assessed. Body weight gain and the serum levels of prolactin were significantly increased by sulpiride; in addition, a significant positive correlation was observed between prolactin levels and body weight gain. Other endocrine parameters were not significantly affected by the drug. These short-term results show that in healthy men, body weight can be increased by antipsychotic drug administration; thi...Continue Reading

Citations

Feb 13, 2001·Acta Psychiatrica Scandinavica·T Baptista
Mar 14, 2008·Pituitary·Amal Shibli-Rahhal, Janet Schlechte
Mar 23, 2002·Journal of Clinical Psychopharmacology·Shubulade SmithVeronica O'Keane
Aug 12, 1999·Acta Psychiatrica Scandinavica·T Baptista
Dec 13, 2003·The Journal of Nervous and Mental Disease·Gail L DaumitDaniel E Ford
Nov 26, 2009·Pharmacology & Therapeutics·Gavin P Reynolds, Shona L Kirk
Oct 20, 2006·Journal of Psychopharmacology·Xiangrong ZhangGavin P Reynolds
Jul 5, 2008·Clinical Drug Investigation·Luca PaniKöksal Alptekin
Jan 5, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·T BaptistaL Hernàndez

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