Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Bridgin G LeeJulie A Blendy

Abstract

Nicotine withdrawal is characterized by both affective and cognitive symptoms. Identifying genetic polymorphisms that could affect the symptoms associated with nicotine withdrawal are important in predicting withdrawal sensitivity and identifying personalized cessation therapies. In the current study we used a mouse model of a non-synonymous single nucleotide polymorphism in the translated region of the brain-derived neurotrophic factor (BDNF) gene that substitutes a valine (Val) for a methionine (Met) amino acid (Val66Met) to examine the relationship between the Val66Met single nucleotide polymorphism and nicotine dependence. This study measured proBDNF and the BDNF prodomain levels following nicotine and nicotine withdrawal and examined a mouse model of a common polymorphism in this protein (BDNF(Met/Met)) in three behavioral paradigms: novelty-induced hypophagia, marble burying, and the open-field test. Using the BDNF knock-in mouse containing the BDNF Val66Met polymorphism we found: (1) blunted anxiety-like behavior in BDNF(Met/Met) mice following withdrawal in three behavioral paradigms: novelty-induced hypophagia, marble burying, and the open-field test; (2) the anxiolytic effects of chronic nicotine are absent in BDNF(Me...Continue Reading

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Citations

Sep 27, 2018·The European Journal of Neuroscience·Burt M Sharp, Hao Chen
Apr 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Julia K BrynildsenJulie A Blendy
May 28, 2019·Molecular Neurobiology·Gofarana WilarKohji Fukunaga
Feb 22, 2017·Journal of Neurochemistry·Juan Pablo ZaninAgustin Anastasia
Sep 6, 2020·Reviews in the Neurosciences·Zeyi HuangSijie Tan
Nov 11, 2020·Behavioural Brain Research·Heidi C MeyerFrancis S Lee
Jun 29, 2021·Translational Neuroscience·Bingxue WuZhaoyan Chen

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