PMID: 2501910Jul 17, 1989Paper

Effects of the benomyl metabolite, carbendazim, on the hypothalamic-pituitary reproductive axis in the male rat

Toxicology
J GoldmanW K McElroy

Abstract

Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. Since it is possible that extragonadal changes contribute to the appearance of such effects, the present study focused on the presence of concurrent endocrine changes in the hypothalamic and pituitary components of the brain-pituitary-testicular axis. Subchronic administration of MBC (50, 100, 200 or 400 mg/kg) was found to cause a dose-related elevation in serum follicle stimulating hormone (FSH) and pituitary luteinizing hormone (LH). Values for prolactin and thyroid-stimulating hormone remained unchanged. No statistical differences in gonadotropin-releasing hormone concentrations were present in mediobasal hypothalamus, although an elevation in anterior hypothalamic values was found at the low dose, followed by a dose-related decline. These findings demonstrate that previously reported gonadal differences following subchronic exposure to carbendazim are accompanied by alterations elsewhere in the reproductive system which appear to involve both changes in Sertoli cell-pituitary feedback signals and direct effects of the compound on the central nervous system.

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Citations

Feb 28, 2002·Journal of Pharmaceutical and Biomedical Analysis·Lee JiaSteve D Weitman
Aug 2, 2013·The Onderstepoort Journal of Veterinary Research·Wahabu H KimaroHerman B Groenewald
Feb 24, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M A AkbarshaA Faridha
Jul 1, 1989·Toxicology and Applied Pharmacology·R L CooperW K McElroy
Aug 23, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A A Mahgoub, A H El-Medany
May 28, 2014·Regulatory Toxicology and Pharmacology : RTP·Elkiane Macedo RamaEstefania Gastaldello Moreira
Jan 24, 2015·Toxicology and Industrial Health·Hamdy Aa AlyAbdel-Moneim M Osman
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
Mar 9, 2021·Morphologie : Bulletin De L'Association Des Anatomistes·A O OyewopoG O Eweoya
Mar 8, 2017·Analytical Chemistry·Shimaa Eissa, Mohammed Zourob
May 12, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Quaiser SaquibJaved Musarrat

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