PMID: 2898256Apr 1, 1988

Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists

British Journal of Clinical Pharmacology
O J RobbJ Young


1. The selective beta 2-adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1-adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2-selective antagonism does not play a role in the hypotensive action of beta-adrenoceptor antagonists.


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Related Concepts

ICI 118551, hydrochloride
Adrenergic beta-Antagonists
Diastolic Blood Pressure
Pulse Rate
Hypertensive Disease

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