PMID: 2898256Apr 1, 1988

Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1-adrenoceptor antagonists

British Journal of Clinical Pharmacology
O J RobbJ Young

Abstract

1. The selective beta 2-adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1-adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2-selective antagonism does not play a role in the hypotensive action of beta-adrenoceptor antagonists.

References

Mar 15, 1986·British Medical Journal·M J Gardner, D G Altman
Apr 1, 1981·The Journal of Pharmacy and Pharmacology·S R O'Donnell, K Walduck
Dec 1, 1983·British Journal of Clinical Pharmacology·A E Tattersfield, D J Cragg
May 1, 1983·Journal of Cardiovascular Pharmacology·A J BilskiJ L Wale
Dec 8, 1983·The New England Journal of Medicine·M J BrownM B Murphy
Aug 1, 1981·British Journal of Clinical Pharmacology·J WebsterJ C Petrie

Citations

Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S J CooperA Gilliland
Jan 11, 1991·Fundamental & Clinical Pharmacology·A J NicholsR R Ruffolo
Jan 28, 2012·Cardiovascular Therapeutics·Dennis LadageKlara Brixius
Oct 8, 2009·Clinical Science·Brian J Lipworth, Peter A Williamson
Feb 13, 2019·American Journal of Hypertension·Alastair J Sandilands, Kevin M O'Shaughnessy
Nov 1, 2001·The Cochrane Database of Systematic Reviews·M CheineK Wahlbeck
Jul 31, 2020·Military Medicine·Cody Armstrong, Michelle R Kapolowicz
Jan 1, 2014·Psychiatry and Clinical Neurosciences·Ken-ichi YamamotoMitsunobu Yoshii
Feb 17, 1990·BMJ : British Medical Journal·B R Ballinger

Related Concepts

ICI 118551, hydrochloride
Adrenergic beta-Antagonists
Diastolic Blood Pressure
Pulse Rate
Hypertensive Disease
Propanolamines

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.