PMID: 22332540Feb 16, 2012Paper

Effects of the beta2-adrenergic receptor Gln27Glu variation on changes of serum lipid and apolipoprotein ratios induced by a high-carbohydrate/low-fat diet in healthy youth

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Guo-jin OuMei Fan

Abstract

To investigate the effects of the Gln27Glu polymorphism of beta2-adrenergic receptor (beta2AR) on serum lipid and apolipoprotein ratios and its interaction with high-carbohydrate/low-fat (HC/LF) diet on the ratios in healthy youth. After on a washout diet for seven days, fifty six healthy young subjects were given the HC/LF diet for six days. The 12 hour-fasting serum lipids and apolipoproteins (apo) AI and B100 were measured on the 1st, the 8th and the 14th days. The ratios of TG/HDL-C, log (TG/HDL-C), TC/HDL-C, LDL-C/HDL-C and apoAI/apoB100 were calculated. The polymorphism of Gln27Glu was analyzed by PCR-RFLP method. No significant differences were found of the lipid and apolipoprotein ratios at baseline and before the HC/LF diet between the subjects with the CC genotype (wide type) and the G carriers (mutation carriers) in the whole study sample or the males and the females separately. The G carriers had a significantly higher level of log (TG/HDL-C) (P=0.038) than the subjects with the CC genotype did after the HC/LF diet in the whole study sample but not in the males and the females separately. Significant decreases of LDL-C/HDL-C and TC/HDL-C were observed in all the subjects after the HC/LF diet when compared with those...Continue Reading

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