Effects of the bioconcentration and parental transfer of environmentally relevant concentrations of difenoconazole on endocrine disruption in zebrafish (Danio rerio)

Environmental Pollution
Miaomiao TengChengju Wang

Abstract

Difenoconazole, a typical triazole fungicide, inhibits lanosterol-14R-demethylase (CYP51) to prevent fungal sterol synthesis and its residues are frequently detected in the environment due to its wide application. Previous studies have demonstrated that difenoconazole altered the triglyceride levels, and gene expression relevant to cholesterol biosynthesis in zebrafish. However, endocrine-disruption in the hypothalamus-pituitary-gonadal-liver (HPGL) axis, the effects of transferring to offspring, and the underlying mechanisms of difenoconazole in aquatic organisms are still unknown. In this study, we defined the effects of difenoconazole at environmental concentrations on endocrine disturbance using zebrafish as an experimental model. The results indicated that difenoconazole induced a significant change in the somatic index, and pathological variations in tissues, and steroid hormone levels. RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3β, hsd11β, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and erα genes in livers. In addition, difenoconazole exposure in parental zebrafish affected the hatchability and length of its offspring. Moreover, the burd...Continue Reading

Citations

Sep 5, 2019·Environmental Science and Pollution Research International·André Luis Correa de BarrosGilmare Antônia da Silva
Nov 9, 2019·Environmental Science and Pollution Research International·Viviane Ribas PereiraAna Paula Alves Favareto
Nov 19, 2018·Environmental Science and Pollution Research International·Hie Ling WongColin D Brown
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Apr 10, 2021·Environmental Science and Pollution Research International·Ming JiaWentao Zhu
May 29, 2021·Environmental Science and Pollution Research International·Guangzhu DongGuizhen Du
Jun 15, 2021·Chemico-biological Interactions·Sathisaran UmamaheswariMathan Ramesh
Apr 24, 2020·Journal of Agricultural and Food Chemistry·Zhaoxian ZhangMingHua Wang
Dec 1, 2021·Chemical Research in Toxicology·Sathisaran UmamaheswariMathan Ramesh
Jan 30, 2022·The Science of the Total Environment·Tao HuangChristopher J Martyniuk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.