Abstract
Difenoconazole, a typical triazole fungicide, inhibits lanosterol-14R-demethylase (CYP51) to prevent fungal sterol synthesis and its residues are frequently detected in the environment due to its wide application. Previous studies have demonstrated that difenoconazole altered the triglyceride levels, and gene expression relevant to cholesterol biosynthesis in zebrafish. However, endocrine-disruption in the hypothalamus-pituitary-gonadal-liver (HPGL) axis, the effects of transferring to offspring, and the underlying mechanisms of difenoconazole in aquatic organisms are still unknown. In this study, we defined the effects of difenoconazole at environmental concentrations on endocrine disturbance using zebrafish as an experimental model. The results indicated that difenoconazole induced a significant change in the somatic index, and pathological variations in tissues, and steroid hormone levels. RT-PCR experiments further confirmed that difenoconazole significantly induced expression alteration of lhr, hsd3β, hsd11β, cyp19a in the ovary and star, cyp19a, cyp3c1 in the testis, and erα genes in livers. In addition, difenoconazole exposure in parental zebrafish affected the hatchability and length of its offspring. Moreover, the burd...Continue Reading
Citations
Sep 5, 2019·Environmental Science and Pollution Research International·André Luis Correa de BarrosGilmare Antônia da Silva
Nov 9, 2019·Environmental Science and Pollution Research International·Viviane Ribas PereiraAna Paula Alves Favareto
Nov 19, 2018·Environmental Science and Pollution Research International·Hie Ling WongColin D Brown
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Jun 2, 2020·Environmental Pollution·Jinhua JiangXueping Zhao
May 22, 2020·The Science of the Total Environment·Ranran ZhouPing Lu
Apr 10, 2021·Environmental Science and Pollution Research International·Ming JiaWentao Zhu
Jan 14, 2020·Aquatic Toxicology·Julie De OliveiraNathalie Hinfray
Apr 14, 2021·Ecotoxicology and Environmental Safety·Jiansheng ZhuXia Chi
Jun 2, 2020·The Science of the Total Environment·Kannan MaharajanMathan Ramesh
May 29, 2021·Environmental Science and Pollution Research International·Guangzhu DongGuizhen Du
Jun 15, 2021·Chemico-biological Interactions·Sathisaran UmamaheswariMathan Ramesh
Jul 7, 2021·The Science of the Total Environment·Jinhua JiangXueping Zhao
Oct 21, 2020·Chemosphere·Sathisaran UmamaheswariMathan Ramesh
Apr 24, 2020·Journal of Agricultural and Food Chemistry·Zhaoxian ZhangMingHua Wang
Nov 4, 2020·Environmental Science & Technology·Le QianChengju Wang
Dec 1, 2021·Chemical Research in Toxicology·Sathisaran UmamaheswariMathan Ramesh
Dec 9, 2021·Environmental Toxicology·Ruirui LiYang Zhang
Jan 16, 2022·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jesudass SuthaMathan Ramesh
Jan 30, 2022·The Science of the Total Environment·Tao HuangChristopher J Martyniuk