Effects of the C825T polymorphism of the GNB3 gene on body adiposity and blood pressure in fertile and menopausal women: a population-based study

Journal of Hypertension
E CasigliaA C Pessina

Abstract

The 825T allele of the GNB3 gene is implicated in adipose distribution, predisposing to obesity and hypertension. Menopause is also considered a condition leading to excess adiposity and hypertension. The aim of the present study was to clarify whether the effects of menopause on body weight and blood pressure are influenced by the C825T polymorphism of the GNB3 gene. The study involved 1339 subjects (43% men) aged 18-95 years, genotyped at the GNB3 825 locus, undergoing, in an epidemiological population-based frame, questionnaire, anthropometrics and blood examinations. Mean skinfold thickness (MST), truncal obesity and excess subcutaneous adiposity (MST greater than median) were higher in women than in men. A significant interaction was detected between menopausal status and the C825T polymorphism (Pint > 0.0001). MST, truncal obesity and excess subcutaneous adiposity were lower in CC fertile than menopausal women, but were comparable in TT fertile and menopausal women. In a multivariate logistic model for excess subcutaneous adiposity, the relative risk of menopause was 4.12 (95% confidence interval 2.35-7.22) in CC women but was insignificant in the other two genotypes. In fertile women only, higher systolic blood pressure ...Continue Reading

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Citations

Jan 16, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Edoardo CasigliaPaolo Palatini
Dec 17, 2011·Vascular Health and Risk Management·Paolo PalatiniKalina Kawecka-Jaszcz
Aug 16, 2011·Journal of Women's Health·Edoardo CasigliaPaolo Palatini
Jan 12, 2013·Journal of Women's Health·Edoardo CasigliaPaolo Palatini
Oct 14, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·E CasigliaA C Pessina
Nov 20, 2013·Neurology Research International·Edoardo CasigliaPatrizia Bisiacchi
Jun 26, 2015·Obesity·Valérie TikhonoffPaolo Palatini
Mar 27, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Edoardo Casiglia, Valérie Tikhonoff
Sep 26, 2013·American Journal of Hypertension·Edoardo CasigliaPaolo Palatini
Jan 20, 2012·American Journal of Hypertension·Edoardo CasigliaPaolo Palatini
Feb 25, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Edoardo Casiglia, Valérie Tikhonoff
May 27, 2016·Biomarker Insights·Neveen Salah El Din HemimiMona Mohamed Abdelsalam
Sep 4, 2010·Journal of Clinical Psychopharmacology·Hui Hua ChangPo See Chen
Mar 23, 2019·Journal of Human Hypertension·Valérie TikhonoffPaolo Spinella

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