PMID: 6294681Oct 1, 1982

Effects of the combination of tripelennamine and pentazocine at the behavioral and molecular levels

Pharmacology, Biochemistry, and Behavior
H E Shannon, T P Su

Abstract

The purpose of the present experiments was to determine if the antihistamine tripelennamine potentiates the morphine-like effects of the narcotic-antagonist analgesic pentazocine at the behavioral level or the molecular level or both. At the behavioral level, the effects of pentazocine were determined alone and in combination with tripelennamine in rats trained to discriminate between saline and either morphine or the psychotomimetic narcotic derivative SKF 10,047. The interaction between pentazocine and tripelennamine were also evaluated in the guinea-pig ileum preparation and in the [3H]-naloxone opiate receptor binding assay. Tripelennamine significantly enhanced the morphine-like discriminative stimulus effects of pentazocine and markedly reduced the SKF 10,047-like stimulus effects of pentazocine. Naloxone antagonized the morphine-like effects of pentazocine plus tripelennamine. Pentazocine significantly constricted pupils in the rat, an effect which was additive with the mydriatic effects of tripelennamine. Inhibition of the twitch-height of the electrically stimulated guinea-pig ileum by pentazocine was not affected by tripelennamine. Further, tripelennamine did not modify the Ke for naloxone in antagonizing pentazocine....Continue Reading

References

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Citations

Jan 1, 1985·Psychopharmacology·C A KarasA Poling
Oct 4, 1989·European Journal of Pharmacology·D Huston-LyonsC Kornetsky
Dec 12, 1989·European Journal of Pharmacology·N NishidaM Fujino
Jan 1, 1990·Life Sciences·N M GrayD P Taylor
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·K P NanryA Poling
Dec 1, 1983·Pharmacology, Biochemistry, and Behavior·J ClearyA Poling
Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·E M Unterwald, C Kornetsky
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·S Y Yeh
Feb 1, 1988·Pharmacology, Biochemistry, and Behavior·A H OlivetoL A Dykstra
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·D B Vaupel
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·T J Hudzik, B L Slifer
Oct 25, 2003·European Journal of Pharmacology·Maryam EidiLeili Sepehrara
Oct 2, 2002·European Journal of Pharmacology·Mohammad-Reza ZarrindastShahrbano Oryan
May 15, 2001·Journal of Clinical Pharmacy and Therapeutics·R B Raffa
Apr 28, 2012·Drug Development and Industrial Pharmacy·David J Mastropietro, Hossein Omidian
Jan 12, 2010·Behavioural Brain Research·E DereJ P Huston
Dec 17, 2008·European Journal of Pharmacology·Ken KurodaChiaki Kamei
Oct 22, 2008·Pharmacology, Biochemistry, and Behavior·Zhixia Wang, William L Woolverton
Jun 26, 2007·Neuroscience Letters·Ying-xia GongZhong Chen
Jan 2, 2007·European Journal of Pharmacology·Zhixia Wang, William L Woolverton
Jun 1, 1992·Drug and Alcohol Dependence·P M Beardsley, R L Balster
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·G J Schaefer
Jan 1, 1984·The Journal of Pharmacy and Pharmacology·N L VadlamaniA L Misra
Dec 1, 1983·The International Journal of the Addictions·W R True, J S Pevnick

Related Concepts

SK&F 10047, monooxalate
Metazoa
Brain
Dimedrol
Discrimination (Process of Differentiation)
Drug Augmentation
Cavia porcellus
Ileum
Memory Training
Morphine Sulfate (2: 1), Pentahydrate

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